Uzal Cem, Durmus-Altun Gulay, Caloglu Murat, Ergülen Alev, Altaner Semsi, Yigitbasi N Omer
Department of Radiation Oncology, Trakya University Medical Faculty, Edirne, Turkey.
Int J Radiat Oncol Biol Phys. 2004 Oct 1;60(2):564-9. doi: 10.1016/j.ijrobp.2004.05.045.
The purpose of this study was to determine by using (99m)Tc-diethylenetriaminepentaacetic acid (DTPA) lung scintigraphy whether amifostine given before irradiation protects alveolocapillary integrity in a rabbit model.
Twenty white New Zealand rabbits were randomly divided into 4 groups: (1) control (CONT), (2) amifostine alone (AMF), (3) radiation (RAD), and (4) radiation plus amifostine (RAD+AMF). The AMF and RAD+AMF groups received amifostine. The RAD and RAD+AMF groups were irradiated to the right hemithorax with a single dose of 20 Gy using a (60)Co treatment unit. Amifostine (200 mg/kg) was given i.p. 30 min before irradiation. The (99m)Tc-DTPA radioaerosol study was performed 14 day after irradiation.
The mean clearance rate of (99m)Tc-DTPA in control subjects was 140 +/- 21 min. The highest t((1/2)) value was noted in the RAD group (603 +/- 105 min, p = 0.001). There were no significant differences between the (99m)Tc-DTPA lung clearance rates of the CONT, RAD+AMF (238 +/- 24 min), and AMF groups (227 +/- 54 min). The mean penetration index values of CONT, RAD, AMF, and RAD+AMF are 63% +/- 1.6%, 63% +/- 2.5%, 60% +/- 2.9%, and 63% +/- 2%, respectively.
We concluded that amifostine treatment before the lung irradiation protects the lung alveolocapillary integrity. This study confirms the protective effect of amifostine in an acute phase of radiation lung injury.
本研究旨在通过使用（99m）锝-二乙烯三胺五乙酸（DTPA）肺闪烁显像来确定在兔模型中，放疗前给予氨磷汀是否能保护肺泡毛细血管的完整性。
20只白色新西兰兔随机分为4组：（1）对照组（CONT），（2）单纯氨磷汀组（AMF），（3）放疗组（RAD），（4）放疗加氨磷汀组（RAD+AMF）。AMF组和RAD+AMF组接受氨磷汀治疗。RAD组和RAD+AMF组使用（60）Co治疗单元对右侧半胸给予单次20 Gy的照射。在照射前30分钟经腹腔注射氨磷汀（200 mg/kg）。照射后14天进行（99m）Tc-DTPA放射性气溶胶研究。
对照组中（99m）Tc-DTPA的平均清除率为140±21分钟。RAD组的t（1/2）值最高（603±105分钟，p = 0.001）。CONT组、RAD+AMF组（238±24分钟）和AMF组（227±54分钟）的（99m）Tc-DTPA肺清除率之间无显著差异。CONT组、RAD组、AMF组和RAD+AMF组的平均渗透指数值分别为63%±1.6%、63%±2.5%、60%±2.9%和63%±2%。
我们得出结论，肺部放疗前给予氨磷汀治疗可保护肺泡毛细血管的完整性。本研究证实了氨磷汀在放射性肺损伤急性期的保护作用。
