氨磷汀对辐射诱发的急性肺毒性的保护作用：通过（99m）Tc-DTPA经肺泡清除率进行检测

The protective effect of amifostine on radiation-induced acute pulmonary toxicity: detection by (99m)Tc-DTPA transalveolar clearances.

作者信息

Uzal Cem, Durmus-Altun Gulay, Caloglu Murat, Ergülen Alev, Altaner Semsi, Yigitbasi N Omer

机构信息

Department of Radiation Oncology, Trakya University Medical Faculty, Edirne, Turkey.

出版信息

Int J Radiat Oncol Biol Phys. 2004 Oct 1;60(2):564-9. doi: 10.1016/j.ijrobp.2004.05.045.

DOI:10.1016/j.ijrobp.2004.05.045

PMID:15380593

Abstract

PURPOSE

The purpose of this study was to determine by using (99m)Tc-diethylenetriaminepentaacetic acid (DTPA) lung scintigraphy whether amifostine given before irradiation protects alveolocapillary integrity in a rabbit model.

METHODS AND MATERIALS

Twenty white New Zealand rabbits were randomly divided into 4 groups: (1) control (CONT), (2) amifostine alone (AMF), (3) radiation (RAD), and (4) radiation plus amifostine (RAD+AMF). The AMF and RAD+AMF groups received amifostine. The RAD and RAD+AMF groups were irradiated to the right hemithorax with a single dose of 20 Gy using a (60)Co treatment unit. Amifostine (200 mg/kg) was given i.p. 30 min before irradiation. The (99m)Tc-DTPA radioaerosol study was performed 14 day after irradiation.

RESULTS

The mean clearance rate of (99m)Tc-DTPA in control subjects was 140 +/- 21 min. The highest t((1/2)) value was noted in the RAD group (603 +/- 105 min, p = 0.001). There were no significant differences between the (99m)Tc-DTPA lung clearance rates of the CONT, RAD+AMF (238 +/- 24 min), and AMF groups (227 +/- 54 min). The mean penetration index values of CONT, RAD, AMF, and RAD+AMF are 63% +/- 1.6%, 63% +/- 2.5%, 60% +/- 2.9%, and 63% +/- 2%, respectively.

CONCLUSIONS

We concluded that amifostine treatment before the lung irradiation protects the lung alveolocapillary integrity. This study confirms the protective effect of amifostine in an acute phase of radiation lung injury.

摘要

目的

本研究旨在通过使用（99m）锝-二乙烯三胺五乙酸（DTPA）肺闪烁显像来确定在兔模型中，放疗前给予氨磷汀是否能保护肺泡毛细血管的完整性。

方法与材料

20只白色新西兰兔随机分为4组：（1）对照组（CONT），（2）单纯氨磷汀组（AMF），（3）放疗组（RAD），（4）放疗加氨磷汀组（RAD+AMF）。AMF组和RAD+AMF组接受氨磷汀治疗。RAD组和RAD+AMF组使用（60）Co治疗单元对右侧半胸给予单次20 Gy的照射。在照射前30分钟经腹腔注射氨磷汀（200 mg/kg）。照射后14天进行（99m）Tc-DTPA放射性气溶胶研究。

结果

对照组中（99m）Tc-DTPA的平均清除率为140±21分钟。RAD组的t（1/2）值最高（603±105分钟，p = 0.001）。CONT组、RAD+AMF组（238±24分钟）和AMF组（227±54分钟）的（99m）Tc-DTPA肺清除率之间无显著差异。CONT组、RAD组、AMF组和RAD+AMF组的平均渗透指数值分别为63%±1.6%、63%±2.5%、60%±2.9%和63%±2%。