Forman D E, Manning W J, Hauser R, Gervino E V, Evans W J, Wei J Y
Charles A. Dana Research Institute Beth Israel Hospital, Boston.
J Gerontol. 1992 Mar;47(2):M56-8. doi: 10.1093/geronj/47.2.m56.
Normal aging is associated with an impairment in early left ventricular diastolic filling. To test the hypothesis that long-term endurance exercise training is associated with enhanced ventricular diastolic filling indices, we compared transmitral pulsed Doppler inflow spectra in healthy young adults; healthy elderly, sedentary subjects (sedentary old); and healthy elderly, endurance athletes (master athletes). Our data demonstrate that, despite an increase in left ventricular mass, early diastolic filling was enhanced in master athletes compared to the sedentary old. Blood pressure of both master athletes and the sedentary olds was greater than the young adults, but the higher blood pressure did not correlate to changes in filling parameters. Resting systolic function and heart rate were not significantly different in all three different groups. Early left ventricular filling indices in master athletes more closely resemble transmitral inflow patterns of healthy young adults. Long-term endurance exercise is associated with physiologic hypertrophy and ventricular filling dynamics more characteristic of the young than the old.
正常衰老与左心室早期舒张期充盈受损有关。为了验证长期耐力运动训练与增强心室舒张期充盈指标相关的假设，我们比较了健康年轻成年人、健康老年久坐不动的受试者（久坐的老年人）以及健康老年耐力运动员（大师级运动员）的经二尖瓣脉冲多普勒流入频谱。我们的数据表明，尽管左心室质量增加，但与久坐的老年人相比，大师级运动员的早期舒张期充盈增强。大师级运动员和久坐的老年人的血压均高于年轻成年人，但较高的血压与充盈参数的变化无关。所有三个不同组的静息收缩功能和心率无显著差异。大师级运动员的左心室早期充盈指标更类似于健康年轻成年人的经二尖瓣流入模式。长期耐力运动与生理性肥大以及更具年轻人而非老年人特征的心室充盈动力学有关。
