Lekavich Carolyn L, Allen Jason D, Bensimhon Daniel R, Bateman Lori A, Slentz Cris A, Samsa Gregory P, Kenjale Aarti A, Duscha Brian D, Douglas Pamela S, Kraus William E
Division of Cardiology, Duke University School of Medicine, Durham, NC, United States.
Division of Cardiovascular Medicine, Department of Kinesiology, University of Virginia, Charlottesville, VA, United States.
Front Cardiovasc Med. 2021 Apr 1;8:638929. doi: 10.3389/fcvm.2021.638929. eCollection 2021.
The goal was studying the differential effects of aerobic training (AT) vs. resistance training (RT) on cardiac and peripheral arterial capacity on cardiopulmonary (CP) and peripheral vascular (PV) function in sedentary and obese adults. In a prospective randomized controlled trial, we studied the effects of 6 months of AT vs. RT in 21 subjects. Testing included cardiac and vascular ultrasoundography and serial CP for ventricular-arterial coupling (Ees/Ea), strain-based variables, brachial artery flow-mediated dilation (BAFMD), and peak VO (pVO mL/kg/min) and peak O-pulse (Op; mL/beat). Within the AT group ( = 11), there were significant increases in rVO of 4.2 mL/kg/min (SD 0.93) ( = 0.001); Op of 1.9 mL/beat (SD 1.3) ( = 0.008) and the brachial artery post-hyperemia peak diameter 0.18 mm (SD 0.08) ( = 0.05). Within the RT group ( = 10) there was a significant increase in left ventricular end diastolic volume 7.0 mL (SD 9.8; = 0.05) and percent flow-mediated dilation (1.8%) (SD 0.47) ( = 0.004). Comparing the AT and RT groups, post exercise, rVO 2.97, (SD 1.22), ( = 0.03), Op 0.01 (SD 1.3), ( = 0.01), peak hyperemic blood flow volume (1.77 mL) (SD 140.69) ( = 0.009), were higher in AT, but LVEDP 115 mL (SD 7.0) ( = 0.05) and Ees/Ea 0.68 mmHg/ml (SD 0.60) = 0.03 were higher in RT. The differential effects of AT and RT in this hypothesis generating study have important implications for exercise modality and clinical endpoints.
目的是研究有氧运动训练（AT）与抗阻训练（RT）对久坐不动的肥胖成年人心脏和外周动脉能力以及心肺（CP）和外周血管（PV）功能的不同影响。在一项前瞻性随机对照试验中，我们研究了21名受试者进行6个月的AT与RT的效果。测试包括心脏和血管超声检查以及用于心室 - 动脉耦合（Ees/Ea）、基于应变的变量、肱动脉血流介导的扩张（BAFMD）以及峰值VO₂（pVO₂ mL/kg/min）和峰值氧脉搏（Op；mL/beat）的系列心肺测试。在AT组（n = 11）中，rVO₂显著增加4.2 mL/kg/min（标准差0.93）（P = 0.001）；Op增加1.9 mL/beat（标准差1.3）（P = 0.008），肱动脉充血后峰值直径增加0.18 mm（标准差0.08）（P = 0.05）。在RT组（n = 10）中，左心室舒张末期容积显著增加7.0 mL（标准差9.8；P = 0.05），血流介导的扩张百分比增加（1.8%）（标准差0.47）（P = 0.004）。比较AT组和RT组，运动后，AT组的rVO₂为2.97（标准差1.22）（P = 0.03），Op为0.01（标准差1.3）（P = 0.01），充血峰值血流量为1.77 mL（标准差140.69）（P = 0.009）更高，但RT组的左心室舒张末期压力为115 mL（标准差7.0）（P = 0.05）和Ees/Ea为0.68 mmHg/ml（标准差0.60）（P = 0.03）更高。在这项产生假设的研究中，AT和RT的不同效果对运动方式和临床终点具有重要意义。
