Afrasyap Lale, Oztürk Güler, Erbaş Deniz
Department of Biochemistry, Faculty of Health, Mugla University, Istanbul, Turkey.
Clin Lab. 2004;50(11-12):703-7.
The purpose of this study was to examine whether the serum levels of nitric oxide end products and the ratio of nitrite to lipoproteins are valid instruments in the clinical follow-up of patients with coronary artery disease. 65 subjects were divided into three groups, including patients with coronary artery disease, silent coronary artery disease and controls. The serum nitrite level and also the ratio of nitrite to high-density lipoprotein were significantly different between the groups. According to the number of obstructed arteries, the serum nitrite level and the ratio of nitrite to high-density lipoprotein were found statistically different between the groups. There was a positive correlation between the serum nitrite level and the ratio of nitrite to high-density lipoprotein and the number of obstructed arteries. In conclusion, the serum nitrite level and ratio of nitrite to high-density lipoprotein may provide a beneficial guide to follow-up the status of patients with coronary artery disease.
本研究的目的是检验一氧化氮终产物的血清水平以及亚硝酸盐与脂蛋白的比率是否为冠心病患者临床随访中的有效指标。65名受试者被分为三组，包括冠心病患者、无症状冠心病患者和对照组。各组之间血清亚硝酸盐水平以及亚硝酸盐与高密度脂蛋白的比率存在显著差异。根据阻塞动脉的数量，发现各组之间血清亚硝酸盐水平以及亚硝酸盐与高密度脂蛋白的比率存在统计学差异。血清亚硝酸盐水平、亚硝酸盐与高密度脂蛋白的比率与阻塞动脉的数量之间存在正相关。总之，血清亚硝酸盐水平以及亚硝酸盐与高密度脂蛋白的比率可能为随访冠心病患者的病情提供有益指导。
