Evers David L, Wang Xin, Huang Eng-Shang
Lineberger Comprehensive Cancer Center, CB No. 7295, Room 32-026, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.
Microbes Infect. 2004 Oct;6(12):1084-93. doi: 10.1016/j.micinf.2004.05.026.
Human cytomegalovirus (HCMV) receptor-ligand interactions and viral entry excite cellular responses such as receptor tyrosine kinase and mitogen-activated protein kinase signaling, cytoskeletal rearrangement, and the induction of transcription factors, prostaglandins, and cytokines. Bi-phasic stimulation of these pathways, excepting interferon, facilitates productive viral infection and likely contributes to viral pathogenesis.
人巨细胞病毒（HCMV）的受体-配体相互作用及病毒进入会激发细胞反应，如受体酪氨酸激酶和丝裂原活化蛋白激酶信号传导、细胞骨架重排以及转录因子、前列腺素和细胞因子的诱导。除干扰素外，这些信号通路的双相刺激促进了病毒的有效感染，并可能导致病毒发病机制。
