5至40岁美国印第安人的2型糖尿病和空腹血糖受损：切罗基糖尿病研究

Type 2 diabetes and impaired fasting glucose in American Indians aged 5-40 years: the Cherokee diabetes study.

作者信息

Lee Elisa T, Begum Momotaz, Wang Wenyu, Blackett Piers R, Blevins Kathleen S, Stoddart Martha, Tolbert Bernadine, Alaupovic Petar

机构信息

Center for American Indian Health Research, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA.

出版信息

Ann Epidemiol. 2004 Oct;14(9):696-704. doi: 10.1016/j.annepidem.2003.10.013.

DOI:10.1016/j.annepidem.2003.10.013

PMID:15380801

Abstract

PURPOSE

To estimate the prevalence of type 2 diabetes and impaired fasting glucose (IFG) and to study several potential risk factors for type 2 diabetes among Oklahoma Cherokees aged 5 to 40 years.

METHODS

A random sample of 2205 members of the Cherokee Nation of Oklahoma aged 5 to 40 years was recruited. Demographic, clinical, and laboratory data were collected. Type 2 diabetes and IFG were determined using the 1997 American Diabetes Association (ADA) criteria. Relationships between type 2 diabetes and potential risk factors were examined by univariate and multivariate regression methods.

RESULTS

According to ADA criteria, the age-adjusted prevalence proportions of type 2 diabetes were 4.3% in females and 4.8% in males. Among the 89 individuals who had type 2 diabetes, 31 were newly diagnosed. Thirty-two (1.5%, 18 females and 14 males) were found to have IFG. The prevalence of type 2 diabetes and IFG increased with age, number of parents with diabetes, obesity, degree of Indian heritage, high triglyceride value, and low HDL cholesterol.

CONCLUSIONS

The increasing prevalence of type 2 diabetes in young American Indians is alarming. The findings must be disseminated to the Indian communities and their health care providers. Preventive measures and early detection programs must be designed and implemented for children and adolescents in this population.

摘要

目的

评估2型糖尿病和空腹血糖受损（IFG）的患病率，并研究俄克拉荷马州切罗基族5至40岁人群中2型糖尿病的几种潜在危险因素。

方法

招募了2205名年龄在5至40岁之间的俄克拉荷马州切罗基族成员作为随机样本。收集了人口统计学、临床和实验室数据。采用1997年美国糖尿病协会（ADA）标准确定2型糖尿病和IFG。通过单变量和多变量回归方法研究2型糖尿病与潜在危险因素之间的关系。

结果

根据ADA标准，2型糖尿病的年龄调整患病率在女性中为4.3%，在男性中为4.8%。在89名患有2型糖尿病的个体中，31例为新诊断病例。发现32例（1.5%，18例女性和14例男性）患有IFG。2型糖尿病和IFG的患病率随年龄、患糖尿病的父母数量、肥胖、印第安血统程度、高甘油三酯值和低高密度脂蛋白胆固醇而增加。