Magliano Dianna J, Sacre Julian W, Harding Jessica L, Gregg Edward W, Zimmet Paul Z, Shaw Jonathan E
Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Monash University, School of Public Health and Preventive Medicine, Melbourne, Victoria, Australia.
Nat Rev Endocrinol. 2020 Jun;16(6):321-331. doi: 10.1038/s41574-020-0334-z. Epub 2020 Mar 20.
Accumulating data suggest that type 2 diabetes mellitus (T2DM) in younger people (aged <40 years), referred to as young-onset T2DM, has a more rapid deterioration of β-cell function than is seen in later-onset T2DM. Furthermore, individuals with young-onset T2DM seem to have a higher risk of complications than those with type 1 diabetes mellitus. As the number of younger adults with T2DM increases, young-onset T2DM is predicted to become a more frequent feature of the broader diabetes mellitus population in both developing and developed nations, particularly in certain ethnicities. However, the magnitude of excess risk of premature death and incident complications remains incompletely understood; likewise, the potential reasons for this excess risk are unclear. Here, we review the evidence pertaining to young-onset T2DM and its current and future burden of disease in terms of incidence and prevalence in both developed and developing nations. In addition, we highlight the associations of young-onset T2DM with premature mortality and morbidity.
越来越多的数据表明，年轻人（年龄<40岁）中的2型糖尿病（T2DM），即早发型T2DM，其β细胞功能的恶化速度比晚发型T2DM更快。此外，早发型T2DM患者似乎比1型糖尿病患者有更高的并发症风险。随着患有T2DM的年轻成年人数量增加，预计早发型T2DM将在发展中国家和发达国家的更广泛糖尿病患者群体中成为更常见的特征，尤其是在某些种族中。然而，过早死亡和并发疾病的额外风险程度仍未完全了解；同样，这种额外风险的潜在原因也不清楚。在此，我们回顾了与早发型T2DM相关的证据，以及其在发达国家和发展中国家的发病率和患病率方面当前和未来的疾病负担。此外，我们强调了早发型T2DM与过早死亡和发病的关联。
