来自拟灰毛婆婆纳亚种的酰化黄酮类化合物和酚苷。
Acylated flavonoids and phenol glycosides from Veronica thymoides subsp. pseudocinerea.
作者信息
Saracoglu Iclal, Varel Mehtap, Harput U Sebnem, Nagatsu Akito
机构信息
Faculty of Pharmacy, Department of Pharmacognosy, Hacettepe University, 06100 Ankara, Turkey.
出版信息
Phytochemistry. 2004 Aug;65(16):2379-85. doi: 10.1016/j.phytochem.2004.05.011.
A new acylated flavone glucoside, 3'-hydroxyscutellarein 7-O-(6''-O-protocatechuoyl)-beta-glucopyranoside (1), and a new phenol glucoside, 3,5-dihydroxyphenethyl alcohol 3-O-beta-glucopyranoside (6) were isolated from Veronica thymoides subsp. pseudocinerea together with seven known flavone, phenol and lignan glycosides; 3'-hydroxyscutellarein 7-O-(6''-O-trans-feruloyl)-beta-glucopyranoside (2), 3'-hydroxy, 6-O-methylscutellarein 7-O-beta-glucopyranoside (3), luteolin 7-O-beta-glucopyranoside (4), isoscutellarein 7-O-(6'''-O-acetyl)-beta-allopyranosyl (1''' --> 2'')-beta-glucopyranoside (5), 3,4-dihydroxyphenethyl alcohol 8-O-beta-glucopyranoside (7), benzyl alcohol 7-O-beta-xylopyranosyl (1" --> 2')-beta-glucopyranoside (8), and (+)-syringaresinol 4'-O-beta-glucopyranoside (9). Compounds 2, 3 and 7-9 were reported for the first time in the genus Veronica. The structures of the isolates were determined by means of spectroscopic (UV, IR, 1D and 2D NMR, HR ESI-MS) methods. Isolated compounds (1-7) exhibited potent radical scavenging activity against the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical.
从拟灰叶婆婆纳中分离出一种新的酰化黄酮苷，即3'-羟基野黄芩素7-O-(6''-O-原儿茶酰基)-β-D-吡喃葡萄糖苷（1），以及一种新的酚苷，即3,5-二羟基苯乙醇3-O-β-D-吡喃葡萄糖苷（6），同时还分离出七种已知的黄酮、酚和木脂素苷；3'-羟基野黄芩素7-O-(6''-O-反式阿魏酰基)-β-D-吡喃葡萄糖苷（2）、3'-羟基-6-O-甲基野黄芩素7-O-β-D-吡喃葡萄糖苷（3）、木犀草素7-O-β-D-吡喃葡萄糖苷（4）、异野黄芩素7-O-(6'''-O-乙酰基)-β-D-阿洛吡喃糖基（1'''→2''）-β-D-吡喃葡萄糖苷（5）、3,4-二羟基苯乙醇8-O-β-D-吡喃葡萄糖苷（7）、苯甲醇7-O-β-D-吡喃木糖基（1''→2'）-β-D-吡喃葡萄糖苷（8）以及(+)-丁香树脂醇4'-O-β-D-吡喃葡萄糖苷（9）。化合物2、3和7 - 9在婆婆纳属中首次被报道。通过光谱（紫外、红外、一维和二维核磁共振、高分辨电喷雾电离质谱）方法确定了分离物的结构。分离得到的化合物（1 - 7）对2,2-二苯基-1-苦基肼（DPPH）自由基表现出较强的自由基清除活性。
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