来自大万寿菊的具有抗氧化活性的酰化槲皮万寿菊素糖苷。
Acylated quercetagetin glycosides with antioxidant activity from Tagetes maxima.
作者信息
Parejo Irene, Bastida Jaume, Viladomat Francesc, Codina Carles
机构信息
Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Catalonia, Spain.
出版信息
Phytochemistry. 2005 Oct;66(19):2356-62. doi: 10.1016/j.phytochem.2005.07.004.
The fractionation of a methanolic extract of Tagetes maxima guided for antioxidant activity resulted in the isolation of three acylated quercetagetin glycosides, quercetagetin-7-O-(6-O-caffeoyl-beta-D-glucopyranoside), quercetagetin-7-O-(6-O-p-coumaroyl-beta-D-glucopyranoside) and quercetagetin-7-O-(6-O-galloyl-beta-D-glucopyranoside), as well as four known flavonoid glycosides. The structural elucidation was accomplished by spectroscopic methods (ESI-MS/MS and NMR). The antioxidant activity of fractions and isolated compounds was determined by checking the scavenging activity against three different radicals: 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH*), hydroxyl (OH), and superoxide (O2-). The three isolated compounds exhibited a high radical scavenging activity in comparison with reference compounds.
对万寿菊甲醇提取物进行基于抗氧化活性的分级分离，得到了三种酰化槲皮万寿菊素糖苷，即槲皮万寿菊素-7-O-(6-O-咖啡酰基-β-D-吡喃葡萄糖苷)、槲皮万寿菊素-7-O-(6-O-对香豆酰基-β-D-吡喃葡萄糖苷)和槲皮万寿菊素-7-O-(6-O-没食子酰基-β-D-吡喃葡萄糖苷)，以及四种已知的黄酮类糖苷。通过光谱方法（电喷雾串联质谱和核磁共振）完成了结构解析。通过检测对三种不同自由基的清除活性，即2,2-二苯基-1-苦基肼自由基（DPPH*）、羟基自由基（OH）和超氧阴离子自由基（O2-），来测定各分级部分和分离得到的化合物的抗氧化活性。与参考化合物相比，三种分离得到的化合物表现出较高的自由基清除活性。
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