来自图氏婆婆纳的苯乙醇苷类、环烯醚萜类和一种螺旋甾烷醇皂苷。

Phenylethanoids, iridoids and a spirostanol saponin from Veronica turrilliana.

作者信息

Kostadinova Emanuela P, Alipieva Kalina I, Kokubun Tetsuo, Taskova Rilka M, Handjieva Nedjalka V

机构信息

Institute of Organic Chemistry with Center of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.

出版信息

Phytochemistry. 2007 May;68(9):1321-6. doi: 10.1016/j.phytochem.2007.02.014. Epub 2007 Mar 30.

DOI:10.1016/j.phytochem.2007.02.014

PMID:17399747

Abstract

From the aerial parts of Veronica turrilliana two phenylethanoid glycosides, turrilliosides A and B and a steroidal saponin, turrillianoside were isolated and their structures elucidated as beta-(3,4-dihydroxyphenyl)ethyl-4-O-E-caffeoyl-O-[beta-glucopyranosyl-(1-->4)-alpha-rhamnopyranosyl-(1-->6)]-beta-glucopyranoside, beta-(3,4-dihydroxyphenyl)ethyl-4-O-E-caffeoyl-[6-O-E-feruloyl-beta-glucopyranosyl-(1-->4)-alpha-rhamnopyranosyl-(1-->6)]-beta-glucopyranoside and (23S,25S)-12beta,23-dihydroxyspirost-5-en-3beta-yl O-alpha-rhamnopyranosyl-(1-->4)-beta-glucopyranoside, respectively. Furthermore, eight known glucosides are reported namely, catalpol, catalposide, verproside, amphicoside, isovanilloylcatalpol, aucubin, arbutin, and 6-O-E-caffeoylarbutin, the latter two for the first time in the genus Veronica. The two phenylethanoid glycosides were found to be potent DPPH radical scavengers. All of the tested compounds were inactive against the representative species of fungi and bacteria.

摘要

从图氏婆婆纳的地上部分分离得到了两种苯乙醇苷类化合物，即图氏婆婆纳苷A和B以及一种甾体皂苷，图氏婆婆纳皂苷，并对它们的结构进行了鉴定，分别为β-(3,4-二羟基苯基)乙基-4-O-E-咖啡酰基-O-[β-D-吡喃葡萄糖基-(1→4)-α-L-吡喃鼠李糖基-(1→6)]-β-D-吡喃葡萄糖苷、β-(3,4-二羟基苯基)乙基-4-O-E-咖啡酰基-[6-O-E-阿魏酰基-β-D-吡喃葡萄糖基-(1→4)-α-L-吡喃鼠李糖基-(1→6)]-β-D-吡喃葡萄糖苷和(23S,25S)-12β,23-二羟基螺甾-5-烯-3β-基O-α-L-吡喃鼠李糖基-(1→4)-β-D-吡喃葡萄糖苷。此外，还报道了8种已知的糖苷，即梓醇、梓苷、婆婆纳苷、双角苷、异香草酰梓醇、桃叶珊瑚苷、熊果苷和6-O-E-咖啡酰基熊果苷，后两种是在婆婆纳属中首次发现。发现这两种苯乙醇苷类化合物是有效的DPPH自由基清除剂。所有测试化合物对代表性的真菌和细菌物种均无活性。