来自马达加斯加叶海绵的新型基于半日花烷的倍半萜。

New scalarane-based sesterterpenes from the sponge Phyllospongia madagascarensis.

作者信息

Ponomarenko Ljudmila P, Kalinovsky Anatoly I, Stonik Valentin A

机构信息

Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Prospect 100 let Vladivostoku, 159, Vladivostok 690022, Russia.

出版信息

J Nat Prod. 2004 Sep;67(9):1507-10. doi: 10.1021/np040073m.

DOI:10.1021/np040073m

PMID:15387650

Abstract

Two new natural scalaranes, 16beta-acetoxy-20,24-dimethyl-12,24-dioxo-25-norscalarane and 12beta-hydroxy-20,24-dimethyl-13,18-oxa-25-norscalarane, were isolated from the Madagascaran sponge Phyllospongiamadagascarensis, together with three previously decribed tetracyclic sesterterpenoids, phyllofolactones F, G, and B, and a new artifactual ethyl ether of scalaradisin B. Structure determinations were based on NMR and other spectral data. Compounds 1 and 2 represent new examples of 20,24-dimethyl-25-norscalarane sesterterpenes, and compound 2 has a seven-membered oxacycle that makes its skeletal system unique.

摘要

从马达加斯加海绵Phyllospongiamadagascarensis中分离出两种新的天然四环三萜，16β-乙酰氧基-20,24-二甲基-12,24-二氧代-25-降四环三萜和12β-羟基-20,24-二甲基-13,18-氧杂-25-降四环三萜，以及三种先前已描述的四环倍半萜类化合物，叶叶内酯F、G和B，还有一种新的伪产物——四环三萜B的乙基醚。结构测定基于核磁共振（NMR）和其他光谱数据。化合物1和2代表20,24-二甲基-25-降四环三萜倍半萜的新实例，化合物2具有一个七元氧杂环，使其骨架系统独特。