来自红海海绵直立希氏海绵的抗分枝杆菌类基于半日花烷型的倍半萜。

Antimycobacterial scalarane-based sesterterpenes from the Red Sea sponge Hyrtios erecta.

作者信息

Youssef Diaa T A, Shaala Lamiaa A, Emara Samy

机构信息

Department of Pharmacognosy and Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

出版信息

J Nat Prod. 2005 Dec;68(12):1782-4. doi: 10.1021/np0502645.

DOI:10.1021/np0502645

PMID:16378375

Abstract

A new scalarane-type pentacyclic sesterterpene, sesterstatin 7 (1), was isolated from the Red Sea sponge Hyrtios erecta, together with 16-epi-scalarolbutenolide (2), 25-dehydroxy-12-epi-deacetylscalarin (3), 3-acetylsesterstatin 1 (4), and 21-acetoxydeoxyscalarin. The structure of 1 was elucidated by spectroscopic data interpretation. Sesterstatin 7 (1) showed 63% inhibition of Mycobacterium tuberculosis (H(37)Rv) at a concentration of 6.25 microg/mL. Compound 2 displayed moderate inhibitory activity, while 3 and 4 were weakly active against the same biological target.

摘要

从红海海绵直立希氏海绵中分离出一种新的半日花烷型五环倍半萜——倍半萜他汀7（1），同时还分离出16-表-半日花醇丁烯内酯（2）、25-脱羟基-12-表-脱乙酰基半日花素（3）、3-乙酰基倍半萜他汀1（4）和21-乙酰氧基脱氧半日花素。通过光谱数据解析阐明了1的结构。倍半萜他汀7（1）在浓度为6.25μg/mL时对结核分枝杆菌（H(37)Rv）显示出63%的抑制率。化合物2表现出中等抑制活性，而3和4对相同生物靶点的活性较弱。