Li Hou-Jin, Amagata Taro, Tenney Karen, Crews Phillip
Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California Santa Cruz, Santa Cruz, California 95064, USA.
J Nat Prod. 2007 May;70(5):802-7. doi: 10.1021/np070020f. Epub 2007 Apr 25.
A chemical investigation of the marine sponge Phyllospongia papyracea, collected in Papua New Guinea, initiated by the screening result of a beta-catenin/Tcf4 disruption assay afforded six new bishomoscalarane sesterterpenes containing two rare scalaranes with a cyclobutane ring in the molecule, together with one known scalarane sesterterpene. The structures of the new compounds were elucidated by 1D and 2D spectroscopic techniques. The compounds isolated in this study did not show activity against the beta-catenin and Tcf4 complex.
对采集自巴布亚新几内亚的海洋海绵薄叶纸海绵（Phyllospongia papyracea）进行的化学研究，始于β-连环蛋白/Tcf4破坏试验的筛选结果，从中得到了六种新的双高海松烷型倍半萜烯，其中包含两种分子中带有环丁烷环的罕见海松烷，以及一种已知的海松烷型倍半萜烯。通过一维和二维光谱技术阐明了新化合物的结构。本研究中分离得到的化合物对β-连环蛋白和Tcf4复合物没有活性。
