07H239 - A，一种从海洋来源的炭角菌属真菌LL - 07H239中分离得到的新型具有细胞毒性的桉叶烷倍半萜。

07H239-A, a new cytotoxic eremophilane sesquiterpene from the marine-derived Xylariaceous fungus LL-07H239.

作者信息

McDonald Leonard A, Barbieri Laurel R, Bernan Valerie S, Janso Jeffrey, Lassota Peter, Carter Guy T

机构信息

Wyeth-Research, 401 North Middletown Road, Pearl River, New York 10965, USA.

出版信息

J Nat Prod. 2004 Sep;67(9):1565-7. doi: 10.1021/np049924g.

DOI:10.1021/np049924g

PMID:15387660

Abstract

07H239-A (1), a new eremophilane sesquiterpene from a marine-derived xylariaceous fungus, was isolated, characterized, and shown to be cytotoxic toward a variety of cancer cell lines, with some selectivity for a CCRFCEM leukemia line (IC(50) = 0.9 microg/mL).

摘要

从一种海洋来源的炭角菌中分离出一种新的艾里莫芬烷倍半萜07H239-A (1)，对其进行了表征，并证明它对多种癌细胞系具有细胞毒性，对CCRFCEM白血病细胞系有一定选择性（半数抑制浓度（IC(50)）= 0.9微克/毫升）。