Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
J Nat Prod. 2011 Apr 25;74(4):609-13. doi: 10.1021/np100632g. Epub 2011 Feb 22.
Three new sesquiterpenes, named phomoarcherins A-C (1-3), and four known compounds, kampanol A (4), R-mevalonolactone, ergosterol, and ergosterol peroxide, were isolated from the endophytic fungus Phomopsis archeri. These structures were established on the basis of spectroscopic evidence. The structure and absolute configuration of 1 were confirmed by X-ray crystallographic analysis of its p-bromobenzoate derivative (1a). Compounds 1-4 showed cytotoxicity against five cholangiocarcinoma cell lines (0.1-19.6 μg/mL), while 1 and 2 exhibited weak cytotoxicity against the KB cell line with IC(50) values of 42.1 and 9.4 μg/mL, respectively. In addition, compound 2 showed antimalarial activity against Plasmodium falciparum with an IC(50) value of 0.79 μg/mL.
从内生真菌拟茎点霉（Phomopsis archeri）中分离得到了三种新的倍半萜，分别命名为 phomoarcherins A-C（1-3），以及四种已知化合物，kampanol A（4）、R-甲羟戊酸内酯、麦角甾醇和麦角甾醇过氧化物。这些结构是基于光谱证据确定的。通过对其对溴苯甲酸酯衍生物（1a）的 X 射线晶体学分析，确定了 1 的结构和绝对构型。化合物 1-4 对五种胆管癌细胞系表现出细胞毒性（0.1-19.6 μg/mL），而化合物 1 和 2 对 KB 细胞系表现出较弱的细胞毒性，IC50 值分别为 42.1 和 9.4 μg/mL。此外，化合物 2 对恶性疟原虫（Plasmodium falciparum）表现出抗疟活性，IC50 值为 0.79 μg/mL。
