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一种从真菌木层孔菌属V-27中分离得到的新型苦艾烷倍半萜及其对RBL-2H3细胞脱颗粒的抑制活性。

A new eremophilane sesquiterpene from the fungus Xylaria sp. V-27 and inhibition activity against degranulation in RBL-2H3 cells.

作者信息

Tchoukoua Abdou, Suzuki Takuma, Ariefta Nanang Rudianto, Koseki Takuya, Okawa Yusuke, Kimura Ken-Ichi, Shiono Yoshihito

机构信息

Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.

Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Yamagata, Japan.

出版信息

J Antibiot (Tokyo). 2017 Dec;70(12):1129-1132. doi: 10.1038/ja.2017.120. Epub 2017 Oct 25.

DOI:10.1038/ja.2017.120
PMID:29066795
Abstract

A new eremophilane sesquiterpene, 13,13-dimethoxyintegric acid (1), together with known compound integric acid (2) have been isolated from a fungus, Xylaria sp. V-27, obtained from a dead branch. The structure of 1 was established by means of spectroscopic analyses. 1 and 2 promoted growth restoring activity against the mutant yeast strain (Saccharomyces cerevisiae (zds1Δ erg3Δ pdr1Δ pdr3Δ)) and inhibited degranulation of rat basophilic leukemia RBL-2H3 cells stimulated by immnunoglobulin G + 2,4-dinitrophenylated-bovine serum albumin (IgE+DNP-BSA), thapsigargin and A23187.

摘要

从一根枯树枝上分离得到的真菌——炭角菌属V-27中，分离出一种新的艾里莫芬烷倍半萜13,13-二甲氧基整合酸（1）以及已知化合物整合酸（2）。通过光谱分析确定了1的结构。1和2对突变酵母菌株（酿酒酵母（zds1Δ erg3Δ pdr1Δ pdr3Δ））具有促进生长恢复活性，并抑制免疫球蛋白G + 2,4-二硝基苯基化牛血清白蛋白（IgE+DNP-BSA）、毒胡萝卜素和A23187刺激的大鼠嗜碱性白血病RBL-2H3细胞脱颗粒。

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本文引用的文献

1
Yeast Ca(2+)-signal transduction inhibitors isolated from Dominican amber prevent the degranulation of RBL-2H3 cells through the inhibition of Ca(2+)-influx.从多米尼加琥珀中分离出的酵母钙信号转导抑制剂通过抑制钙内流来阻止RBL-2H3细胞的脱颗粒。
Fitoterapia. 2016 Sep;113:188-94. doi: 10.1016/j.fitote.2016.07.018. Epub 2016 Aug 2.
2
Four eremophilane sesquiterpenes from the mangrove endophytic fungus Xylaria sp. BL321.从红树林内生真菌 Xylaria sp. BL321 中分离得到的 4 种半日花烷倍半萜。
Mar Drugs. 2012 Feb;10(2):340-348. doi: 10.3390/md10020340. Epub 2012 Feb 6.
3
Eremophilane-type sesquiterpenes from the fungus Xylaria sp. BCC 21097.
来自真菌 Xylaria sp. BCC 21097 的半日花烷型倍半萜。
J Nat Prod. 2010 Apr 23;73(4):683-7. doi: 10.1021/np100030x.
4
New eremophilane sesquiterpenoid compounds, eremoxylarins A and B directly inhibit calcineurin in a manner independent of immunophilin.
J Antibiot (Tokyo). 2008 Aug;61(8):496-502. doi: 10.1038/ja.2008.66.
5
07H239-A, a new cytotoxic eremophilane sesquiterpene from the marine-derived Xylariaceous fungus LL-07H239.07H239 - A，一种从海洋来源的炭角菌属真菌LL - 07H239中分离得到的新型具有细胞毒性的桉叶烷倍半萜。
J Nat Prod. 2004 Sep;67(9):1565-7. doi: 10.1021/np049924g.
6
Novel sesquiterpenoids from the fermentation of Xylaria persicaria are selective ligands for the NPY Y5 receptor.
J Org Chem. 2002 Jul 12;67(14):5001-4. doi: 10.1021/jo011054+.