从海洋海绵Suberites domuncula分离出的真菌黑曲霉中的菖蒲烷倍半萜类化合物。

Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula.

作者信息

Liu Hongbing, Edrada-Ebel RuAngelie, Ebel Rainer, Wang Yao, Schulz Barbara, Draeger Siegfried, Müller Werner E G, Wray Victor, Lin Wenhan, Proksch Peter

机构信息

Institut fur Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universitat Dusseldorf, Universitatsstrasse 1, Dusseldorf, Germany.

出版信息

J Nat Prod. 2009 Sep;72(9):1585-8. doi: 10.1021/np900220r.

DOI:10.1021/np900220r

PMID:19778087

Abstract

Seven new drimane sesquiterpenoids (1-3, 6-9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC(50) against L5178Y cell line: 0.6 microg/mL).

摘要

从海洋海绵Suberites domuncula中分离出的真菌Aspergillus ustus的培养物中获得了七种新的菖蒲烷倍半萜（1-3、6-9），以及已知化合物脱氧乌维丁B（4）、松萝酸B（5）和RES-1149-2（10）。通过包括一维和二维核磁共振光谱以及高分辨率质谱在内的光谱分析确定了它们的结构。化合物6、7和10对一组肿瘤细胞系，包括L5178Y、HeLa和PC12细胞，显示出细胞毒性活性，其中7活性最强（对L5178Y细胞系的EC(50)：0.6微克/毫升）。