报告有“睡眠发作”的帕金森病患者的多巴胺受体基因多态性
Dopamine receptor gene polymorphisms in Parkinson's disease patients reporting "sleep attacks".
作者信息
Rissling Ida, Geller Frank, Bandmann Oliver, Stiasny-Kolster Karim, Körner Yvonne, Meindorfner Charlotte, Krüger Hans-Peter, Oertel Wolfgang H, Möller J Carsten
机构信息
Department of Neurology, Philipps-University Marburg, Germany.
出版信息
Mov Disord. 2004 Nov;19(11):1279-84. doi: 10.1002/mds.20245.
Genes encoding proteins involved in dopaminergic transmission are potential candidate genes for the induction of somnolence in Parkinson's disease (PD) because dopaminergic agents have been shown to be associated with sudden onset of sleep (SOS) in PD. We conducted an association study on dopamine D2, D3, and D4 receptor gene polymorphisms comparing 137 PD patients with SOS and 137 PD patients without SOS matched according to drug therapy, disease duration, sex, and age. Our results show a significant association between the dopamine D2 receptor gene polymorphism Taq IA and SOS in PD. No significant association between two other investigated polymorphisms and the phenomenon of "sleep attacks" in PD was observed.
编码参与多巴胺能传递的蛋白质的基因是帕金森病（PD）中嗜睡诱导的潜在候选基因，因为多巴胺能药物已被证明与PD中的突然睡眠发作（SOS）有关。我们进行了一项关于多巴胺D2、D3和D4受体基因多态性的关联研究，比较了137例有SOS的PD患者和137例无SOS的PD患者，这些患者根据药物治疗、病程、性别和年龄进行匹配。我们的结果显示，多巴胺D2受体基因多态性Taq IA与PD中的SOS之间存在显著关联。未观察到其他两个研究的多态性与PD中“睡眠发作”现象之间存在显著关联。
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