Department of Preventive Medicine, Fujian Provincial Key Laboratory of Environment Factors and Cancer, Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350012, China.
Department of Occupational and Environmental Health, School of Public Health, Xinjiang Medical University, Urumqi 830001, China.
Int J Environ Res Public Health. 2020 Nov 5;17(21):8174. doi: 10.3390/ijerph17218174.
Recent studies have shown that incessant job stress could eventually result in sleep dysfunction (SD), and most importantly, the essential role dopamine receptor D2 (DRD2) gene polymorphisms play in the psychopathological mechanism of SD. The Effort-Reward Imbalance scale and the Pittsburgh Sleep Quality Index were both used to access SD and job stress (JS). A significant negative correlation was observed between the sDA levels and SD subscale scores (sleep efficiency, daytime dysfunction). The findings revealed that high levels of JS were linked to a higher SD score (OR = 2.13, 95% CI: 1.46-3.12). Likewise, the homozygous A1A1 genotype of DRD2 rs1800497 was more likely to be associated with SD (OR = 2.90, 95% CI: 1.75-4.82). Compared to participants with low JS and heterozygous A1A2/A2A2 genotype, those with both high JS and homozygous A1A1 genotype had a higher SD score (OR = 5.40, 95% CI: 2.89-10.11). The A1 allele of the DRD2 rs1800497 polymorphism also enhances the likelihood of SD when undergoing JS. Besides, subjects with low JS and the homozygous A1A1 genotype also showed an increased possibility for sleep dysfunction (OR = 2.05, 95% CI: 1.03-4.11). Our results suggest that the DA system may interrelate with JS to affect sleep.
最近的研究表明，持续不断的工作压力最终可能导致睡眠功能障碍（SD），而多巴胺受体 D2（DRD2）基因多态性在 SD 的精神病理学机制中起着至关重要的作用。使用努力-回报失衡量表和匹兹堡睡眠质量指数来评估 SD 和工作压力（JS）。sDA 水平与 SD 子量表评分（睡眠效率、日间功能障碍）呈显著负相关。研究结果表明，高水平的 JS 与更高的 SD 评分相关（OR = 2.13，95%CI：1.46-3.12）。同样，DRD2 rs1800497 的纯合子 A1A1 基因型也更有可能与 SD 相关（OR = 2.90，95%CI：1.75-4.82）。与低 JS 和杂合子 A1A2/A2A2 基因型的参与者相比，JS 高且纯合子 A1A1 基因型的参与者 SD 评分更高（OR = 5.40，95%CI：2.89-10.11）。DRD2 rs1800497 多态性的 A1 等位基因在经历 JS 时也增加了 SD 的可能性。此外，JS 低且纯合子 A1A1 基因型的受试者发生睡眠功能障碍的可能性也增加（OR = 2.05，95%CI：1.03-4.11）。我们的研究结果表明，DA 系统可能与 JS 相互作用影响睡眠。
