Muniz-Junqueira M I, Prata A, Tosta C E
Departamento de Patologia, Faculdade de Ciencias da Saude, Universidade de Brasilia, Brazil.
Am J Trop Med Hyg. 1992 Feb;46(2):132-6. doi: 10.4269/ajtmh.1992.46.132.
Patients infected with schistosomes may develop a clinical picture of chronic salmonellosis. We have investigated the altered function of macrophages capable of playing a role in the development of chronic salmonellosis associated with Schistosoma mansoni in an experimental model. The capacity of mouse peritoneal macrophages to ingest and kill Salmonella was assessed in mice infected with S. mansoni with or without concurrent Salmonella typhimurium infection. Schistosomiasis was associated with a significant decrease in the phagocytic index of macrophages, due to the reduced number of cells engaged in phagocytosis. However, the number of bacteria ingested by these cells was comparable to that of the control group. The bactericidal capacity of macrophages from S. mansoni-infected mice was also significantly lower than that of cells from normal mice. Macrophages from animals infected only with Salmonella typhimurium showed an increased phagocytic capacity. It was concluded that S. mansoni infection alters phagocytosis and intracellular destruction of salmonellae. This demonstration of a novel mechanism of survival of salmonellae represents a step forward in understanding the pathogenesis and management of chronic septicemic salmonellosis.
感染血吸虫的患者可能会出现慢性沙门氏菌病的临床表现。我们在一个实验模型中研究了巨噬细胞功能的改变，这些巨噬细胞在与曼氏血吸虫相关的慢性沙门氏菌病的发展中可能发挥作用。在感染曼氏血吸虫且伴有或不伴有鼠伤寒沙门氏菌并发感染的小鼠中，评估了小鼠腹腔巨噬细胞摄取和杀死沙门氏菌的能力。血吸虫病与巨噬细胞吞噬指数的显著降低有关，这是由于参与吞噬作用的细胞数量减少。然而，这些细胞摄取的细菌数量与对照组相当。感染曼氏血吸虫的小鼠的巨噬细胞杀菌能力也明显低于正常小鼠的细胞。仅感染鼠伤寒沙门氏菌的动物的巨噬细胞显示出吞噬能力增强。得出的结论是，曼氏血吸虫感染会改变沙门氏菌的吞噬作用和细胞内破坏。沙门氏菌这种新的生存机制的证明是在理解慢性败血性沙门氏菌病的发病机制和管理方面向前迈出的一步。
