肌酐与尿酸排泄之间的关系。
Relation between creatinine and uric acid excretion.
作者信息
Nishida Y
机构信息
Health Administration Center, Tokyo University of Foreign Studies, Japan.
出版信息
Ann Rheum Dis. 1992 Jan;51(1):101-2. doi: 10.1136/ard.51.1.101.
Abstract
The relation between creatinine and uric acid metabolism was analysed in 77 male patients with primary gout and 62 healthy male subjects. Significant positive correlations between 24 hour urinary creatinine and uric acid excretion were shown in both groups. The mean urinary creatinine and uric acid excretions in the patients with gout were significantly increased as compared with those of normal male controls. These results suggest that there is a close correlation between creatinine and uric acid synthesis. In addition, it seems that accelerated uric acid synthesis seen in some patients with gout is due to increased creatinine synthesis.
摘要
对77例原发性痛风男性患者和62名健康男性受试者的肌酐与尿酸代谢关系进行了分析。两组24小时尿肌酐与尿酸排泄均呈显著正相关。痛风患者的尿肌酐和尿酸平均排泄量与正常男性对照组相比显著增加。这些结果表明肌酐与尿酸合成之间存在密切相关性。此外，一些痛风患者中所见的尿酸合成加速似乎是由于肌酐合成增加所致。
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本文引用的文献
1
The enzymatic spectrophotometric method for determination of uric acid.
J Lab Clin Med. 1959 Dec;54:903-13.
2
A FAMILIAL DISORDER OF URIC ACID METABOLISM AND CENTRAL NERVOUS SYSTEM FUNCTION.
Am J Med. 1964 Apr;36:561-70. doi: 10.1016/0002-9343(64)90104-4.
3
Purine metabolism during strenuous muscular exercise in man.
Metabolism. 1980 Mar;29(3):254-60. doi: 10.1016/0026-0495(80)90067-0.
4
Ethanol-induced hyperuricemia: evidence for increased urate production by activation of adenine nucleotide turnover.
N Engl J Med. 1982 Dec 23;307(26):1598-602. doi: 10.1056/NEJM198212233072602.
5
Hyperuricemia in acute illness: a poor prognostic sign.
Am J Med. 1982 Jan;72(1):58-62. doi: 10.1016/0002-9343(82)90578-2.
6
Metabolic basis for disorders of purine nucleotide degradation.
Metabolism. 1981 Jun;30(6):616-34. doi: 10.1016/0026-0495(81)90142-6.
7
Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis.
Science. 1967 Mar 31;155(3770):1682-4. doi: 10.1126/science.155.3770.1682.
8
Studies on the mechanism of fructose-induced hyperuricemia in man.
Metabolism. 1972 Aug;21(8):713-21. doi: 10.1016/0026-0495(72)90120-5.
9
Gout with purine overproduction due to increased phosphoribosylpyrophosphate synthetase activity.
Am J Med. 1973 Aug;55(2):232-42. doi: 10.1016/0002-9343(73)90174-5.
10
Accelerated erythrocyte 5-phosphoribosyl-1-pyrophosphate synthesis. A familial abnormality associated with excessive uric acid production and gout.
Biochem Med. 1972 Aug;6(4):310-6. doi: 10.1016/0006-2944(72)90017-8.
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