癫痫患者对卡马西平所致急性精神运动障碍的快速耐受性
Rapid tolerance to acute psychomotor impairment with carbamazepine in epileptic patients.
作者信息
Larkin J G, McKee P J, Brodie M J
机构信息
University Department of Medicine and Therapeutics, Western Infirmary, Glasgow.
出版信息
Br J Clin Pharmacol. 1992 Jan;33(1):111-4. doi: 10.1111/j.1365-2125.1992.tb04009.x.
Thirteen patients with newly diagnosed epilepsy performed a battery of psychomotor function tests before and during the first 12 weeks of carbamazepine (CBZ) therapy. Movement time (P less than 0.025), total choice reaction time (P less than 0.025), finger tapping rate (P less than 0.005) and number cancellation (P less than 0.05) were all significantly impaired after 1 week's treatment, but had returned to baseline by 4 weeks. Mean (+/- s.d.) serum CBZ concentrations and those of its active metabolite CBZ 10,11 epoxide (CBZ-E) were comparable at 1 (CBZ: 8.5 +/- 2.1 mg l-1, CBZ-E: 1.1 +/- 0.68 mg l-1) and 4 weeks (CBZ: 8.1 +/- 4.4 mg l-1, CBZ-E: 0.93 +/- 0.27 mg l-1). These results suggest the rapid development of tolerance to the acute deleterious psychomotor effects of CBZ.
13例新诊断的癫痫患者在卡马西平（CBZ）治疗的前12周期间及之前进行了一系列精神运动功能测试。治疗1周后，运动时间（P<0.025）、总选择反应时间（P<0.025）、手指敲击速率（P<0.005）和数字划消（P<0.05）均显著受损，但在4周时恢复至基线水平。第1周（CBZ：8.5±2.1mg/l，CBZ-E：1.1±0.68mg/l）和第4周（CBZ：8.1±4.4mg/l，CBZ-E：0.93±0.27mg/l）时，平均（±标准差）血清CBZ浓度及其活性代谢物CBZ 10,11环氧化物（CBZ-E）浓度相当。这些结果表明对CBZ急性有害精神运动效应的耐受性迅速发展。
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