卡马西平和苯妥英钠。癫痫患者单药治疗及撤药期间认知效应的比较。

Carbamazepine and phenytoin. Comparison of cognitive effects in epileptic patients during monotherapy and withdrawal.

作者信息

Gallassi R, Morreale A, Lorusso S, Procaccianti G, Lugaresi E, Baruzzi A

机构信息

Institute of Neurology, University of Bologna, Italy.

出版信息

Arch Neurol. 1988 Aug;45(8):892-4. doi: 10.1001/archneur.1988.00520320082020.

DOI:10.1001/archneur.1988.00520320082020

PMID:3395263

Abstract

We compared the cognitive effects of carbamazepine and phenytoin with neuropsychological tests exploring intelligence, vigilance, attention, memory, and visuomotor performances in 25 epileptics (13 receiving carbamazepine and 12 receiving phenytoin) and 26 matched normal controls. Patients were seizure free for at least two years and taking prolonged monotherapy. We also evaluated the effects of drug withdrawal by retesting patients three months after reduction at half drug dose and three months and one year after complete withdrawal. Our findings suggest that phenytoin affects the cognitive functions more than carbamazepine does, although the negative effects of both drugs are reversible by complete therapy withdrawal.

摘要

我们通过神经心理学测试比较了卡马西平和苯妥英对认知功能的影响，这些测试涉及智力、警觉性、注意力、记忆力和视觉运动表现，研究对象包括25名癫痫患者（13名服用卡马西平，12名服用苯妥英）以及26名匹配的正常对照者。患者至少两年无癫痫发作且接受长期单一疗法治疗。我们还通过在将药物剂量减半三个月后、完全停药三个月和一年后对患者重新进行测试，评估了停药的影响。我们的研究结果表明，苯妥英对认知功能的影响比卡马西平更大，尽管两种药物的负面影响在完全停药后均可逆转。