Gillham R A, Williams N, Wiedmann K, Butler E, Larkin J G, Brodie M J
Department of Clinical Psychology, Southern General Hospital, Glasgow, Scotland.
J Neurol Neurosurg Psychiatry. 1988 Jul;51(7):929-33. doi: 10.1136/jnnp.51.7.929.
A battery of psychometric tests was administered to 85 patients with epilepsy, of whom 26 were untreated, 40 received carbamazepine monotherapy and 19 took carbamazepine with another anticonvulsant. Carbamazepine alone had little effect on performance, but carbamazepine polypharmacy produced significant impairment. Increasing concentrations of carbamazepine (four tests) and its active metabolite, carbamazepine 10,11 epoxide (seven tests), correlated with decreasing performance in the monotherapy patients.
对85名癫痫患者进行了一系列心理测量测试，其中26名未接受治疗，40名接受卡马西平单一疗法，19名服用卡马西平并联合另一种抗惊厥药。单独使用卡马西平对测试表现影响不大，但联合使用卡马西平会导致显著损害。在接受单一疗法的患者中，卡马西平浓度升高（四项测试）及其活性代谢物10,11-环氧卡马西平浓度升高（七项测试）与测试表现下降相关。
