4,4'-亚甲基双(2-氯苯胺)对大鼠鸟氨酸脱羧酶活性的诱导作用
Induction of ornithine decarboxylase activity by 4,4'-methylene bis(2-chloroaniline) in the rat.
作者信息
Savage R E, Weigel W W, Krieg E F
机构信息
National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, OH 45226-1998.
出版信息
Cancer Lett. 1992 Feb 14;62(1):63-8. doi: 10.1016/0304-3835(92)90199-6.
The effects of the curative extender 4,4'-methylene bis (2-chloraniline) (MOCA), an established experimental carcinogen that exhibits activity in rat liver, on hepatic ornithine decarboxylase (ODC) activity was investigated. Male Sprague-Dawley rats were injected i.p. with 75 mg/kg MOCA and killed 6, 12, 18, 24, 42 and 48 h later. Stimulation with MOCA of liver cytosolic ODC was first evident at 6 h, peaked at 12 h and returned to control levels by 42 h. The liver enzyme was refractory to stimulation by a second treatment of MOCA within the dosing intervals examined. The magnitude of stimulation of the enzyme by this aromatic amine was dependent on dose and route of administration.
研究了固化剂4,4'-亚甲基双（2-氯苯胺）（MOCA）对肝鸟氨酸脱羧酶（ODC）活性的影响。MOCA是一种已确定的实验性致癌物，在大鼠肝脏中具有活性。给雄性Sprague-Dawley大鼠腹腔注射75 mg/kg MOCA，并在6、12、18、24、42和48小时后处死。MOCA对肝细胞溶质ODC的刺激在6小时时首次明显，在12小时达到峰值，并在42小时恢复到对照水平。在所检查的给药间隔内，肝脏酶对第二次MOCA处理的刺激无反应。这种芳香胺对该酶的刺激程度取决于剂量和给药途径。
Zotero 插件