Albrecht D, Uhlmann A, Davidowa H
Institut für Physiologie (Charité), Humboldt Universität Berlin, Federal Republic of Germany.
Exp Brain Res. 1992;88(1):199-203. doi: 10.1007/BF02259142.
In urethane anesthetized rats neuronal responses of the visual part of nucleus reticularis thalami (vTR) to light were compared with those during pairing light as a conditioned stimulus (CS) with the electrical stimulation of the rat's tail (US). The intensity of the US was adjusted to the minimum required to evoke a slight freezing behavior in the awake rat. The firing rate of most vTR neurons decreased in the period between light and US application (P less than 0.01). Significant response modulations to light were observed in 39% of the units, in most of them they persisted over an extinction period of 15 min. In addition, neurons which were predominantly inhibited by conditioning sometimes changed from regular spiking to a burst pattern. The results support the hypothesis that conditioning related facilitation of geniculate neurons observed in previous experiments can be explained at least partly by disinhibition of geniculate units from vTR.
在氨基甲酸乙酯麻醉的大鼠中，将丘脑网状核视觉部分（vTR）对光的神经元反应与将光作为条件刺激（CS）与大鼠尾巴电刺激（US）配对时的反应进行了比较。US的强度调整为在清醒大鼠中诱发轻微僵住行为所需的最小值。在光和US施加之间的时间段内，大多数vTR神经元的放电率下降（P<0.01）。在39%的单位中观察到对光的显著反应调制，其中大多数在15分钟的消退期内持续存在。此外，主要受条件作用抑制的神经元有时会从规则放电模式转变为爆发模式。这些结果支持了这样一种假设，即先前实验中观察到的与条件作用相关的膝状神经元促进作用至少部分可以通过vTR对膝状单位的去抑制来解释。
