通过A组链球菌反复局部感染诱导兔风湿样心脏病变；与血清病心脏病变的比较。
The induction of rheumatic-like cardiac lesions in rabbits by repeated focal infections with group A streptococci; comparison with the cardiac lesions of serum disease.
作者信息
MURPHY G E, SWIFT H F
出版信息
J Exp Med. 1950 May 1;91(5):485-98. doi: 10.1084/jem.91.5.485.
Abstract
Cardiac lesions like those characteristic of rheumatic fever in man have been induced in a small portion of rabbits that were subjected to successive focal infections with group A streptococci of several serological types. Fresh myocardial interstitial granulomata so induced bear striking resemblance to Aschoff bodies, the histologic hallmarks of human active rheumatic fever; and the fresh and healed lesions found in the cardiac valves, endocardia, epicardia, blood vessels, and aortae of some of these rabbits are homologous with those characteristic of rheumatic fever in man. These experimental myocardial and vascular lesions and those of human rheumatic fever differ in several important respects from the lesions of experimental and human serum disease.
摘要
在一小部分连续受到几种血清型A组链球菌局部感染的兔子身上，诱发了类似人类风湿热特征性的心脏病变。如此诱发的新鲜心肌间质肉芽肿与阿绍夫小体极为相似，而阿绍夫小体是人类活动性风湿热的组织学特征；在其中一些兔子的心脏瓣膜、心内膜、心外膜、血管和主动脉中发现的新鲜和愈合病变与人类风湿热的特征性病变相同。这些实验性心肌和血管病变以及人类风湿热病变在几个重要方面与实验性和人类血清病的病变不同。
相似文献
1
The induction of rheumatic-like cardiac lesions in rabbits by repeated focal infections with group A streptococci; comparison with the cardiac lesions of serum disease.通过A组链球菌反复局部感染诱导兔风湿样心脏病变；与血清病心脏病变的比较。
J Exp Med. 1950 May 1;91(5):485-98. doi: 10.1084/jem.91.5.485.
2
Induction of cardiac lesions, closely resembling those of rheumatic fever, in rabbits following repeated skin infections with group A streptococci.在兔子身上，经A组链球菌反复皮肤感染后诱发的心脏病变，与风湿热的病变极为相似。
J Exp Med. 1949 Jun 1;89(6):687-98. doi: 10.1084/jem.89.6.687.
3
Evidence that Aschoff bodies of rheumatic myocarditis develop from injured myofibers.风湿性心肌炎的阿绍夫小体由受损肌纤维发展而来的证据。
J Exp Med. 1952 Mar;95(3):319-32. doi: 10.1084/jem.95.3.319.
4
The incidence and pathogenesis of myocarditis in rabbits after group A streptococcal pharyngeal infections.A组链球菌咽部感染后家兔心肌炎的发病率及发病机制
J Exp Med. 1956 Jan 1;103(1):173-88. doi: 10.1084/jem.103.1.173.
5
Cellular reactivity studies to streptococcal antigens. Migration inhibition studies in patients with streptococcal infections and rheumatic fever.针对链球菌抗原的细胞反应性研究。对链球菌感染和风湿热患者的迁移抑制研究。
J Clin Invest. 1974 Aug;54(2):439-50. doi: 10.1172/JCI107780.
6
Studies on the generalized Shwartzman reaction. III. Lesions of the myocardium and coronary arteries accompanying the reaction in rabbits prepared by infection with group A streptococci.全身性施瓦茨曼反应的研究。III. 感染A组链球菌制备的家兔在反应过程中出现的心肌和冠状动脉病变
J Exp Med. 1953 May;97(5):751-66. doi: 10.1084/jem.97.5.751.
7
The association of starch-accumulating strains of group A streptococci with acute nephritis and acute rheumatic fever.A组链球菌淀粉积累菌株与急性肾炎和急性风湿热的关联。
J Hyg (Lond). 1959 Jun;57(2):235-47. doi: 10.1017/s0022172400020088.
8
Elevated levels of IgG specific antimyosin antibodies in acute rheumatic fever (ARF): differential profiles of antibodies to myosin and soluble myocardial antigens in ARF, acute glomerulonephritis and group A streptococcal pharyngitis.急性风湿热（ARF）中抗肌球蛋白特异性IgG抗体水平升高：ARF、急性肾小球肾炎和A组链球菌性咽炎中抗肌球蛋白抗体及可溶性心肌抗原的差异特征
J Clin Lab Immunol. 1993;40(4):149-61.
9
QUANTITATIVE ANTISTREPTOKINASE STUDIES IN PATIENTS INFECTED WITH GROUP A HEMOLYTIC STREPTOCOCCI: A COMPARISON WITH SERUM ANTISTREPTOLYSIN AND GAMMA GLOBULIN LEVELS WITH SPECIAL REFERENCE TO THE OCCURRENCE OF RHEUMATIC FEVER.A组溶血性链球菌感染患者的抗链激酶定量研究：与血清抗链球菌溶血素及γ球蛋白水平的比较，特别提及风湿热的发生情况
J Clin Invest. 1948 Jul;27(4):425-34. doi: 10.1172/JCI101986.
10
Experimental nephritis produced in rabbits by inoculation of group A hemolytic streptococci isolated from epidemic nephritis patients. A focal infection experiment in the paranasal sinuses.
Jpn J Microbiol. 1960 Apr;4:105-14. doi: 10.1111/j.1348-0421.1960.tb00158.x.
引用本文的文献
1
Animal models used to examine the role of the environment in the development of autoimmune disease: findings from an NIEHS Expert Panel Workshop.用于研究环境在自身免疫性疾病发展中作用的动物模型：NIEHS 专家小组研讨会的研究结果。
J Autoimmun. 2012 Dec;39(4):285-93. doi: 10.1016/j.jaut.2012.05.020. Epub 2012 Jun 27.
2
The role of infections in autoimmune disease.感染在自身免疫性疾病中的作用。
Clin Exp Immunol. 2009 Jan;155(1):1-15. doi: 10.1111/j.1365-2249.2008.03834.x.
3
Evidence that Aschoff bodies of rheumatic myocarditis develop from injured myofibers.风湿性心肌炎的阿绍夫小体由受损肌纤维发展而来的证据。
J Exp Med. 1952 Mar;95(3):319-32. doi: 10.1084/jem.95.3.319.
4
[Erythema nodosum].[结节性红斑]
Klin Wochenschr. 1959 May 15;37(10):529-34. doi: 10.1007/BF01487325.
5
6
Loss of myocardial contractility induced in isolated mammalian hearts by streptolysin O.链球菌溶血素O对离体哺乳动物心脏诱导的心肌收缩力丧失。
J Exp Med. 1956 Sep 1;104(3):361-73. doi: 10.1084/jem.104.3.361.
7
Selective necrosis of cardiac and skeletal muscle induced experimentally by means of proteolytic enzyme solutions given intravenously.通过静脉注射蛋白水解酶溶液实验性诱导的心肌和骨骼肌选择性坏死。
J Exp Med. 1954 Apr 1;99(4):387-404. doi: 10.1084/jem.99.4.387.
8
[Pathogenesis of experimental streptococcal endocarditis].[实验性链球菌性心内膜炎的发病机制]
Virchows Arch Pathol Anat Physiol Klin Med. 1952 Oct 9;322(3):298-310. doi: 10.1007/BF00963742.
9
Pathogenesis of group A streptococcal infections.A组链球菌感染的发病机制。
Clin Microbiol Rev. 2000 Jul;13(3):470-511. doi: 10.1128/CMR.13.3.470.
10
Streptococcal rheumatic carditis.链球菌性风湿性心脏病
Microbiol Rev. 1983 Mar;47(1):97-120. doi: 10.1128/mr.47.1.97-120.1983.
本文引用的文献
1
Studies on the Myocardial Aschoff Body: I. Descriptive Classification of Lesions.心肌阿绍夫小体的研究：I. 病变的描述性分类
Am J Pathol. 1934 Jul;10(4):467-488.15.
2
Specific Lesions of Peripheral Blood Vessels in Rheumatism.风湿病中周围血管的特异性病变
Am J Pathol. 1926 May;2(3):235-250.11.
3
HISTOLOGICAL AND SEROLOGICAL SEQUENCES IN EXPERIMENTAL HYPERSENSITIVITY.实验性过敏的组织学和血清学序列。
J Exp Med. 1947 May 31;85(6):571-90. doi: 10.1084/jem.85.6.571.
4
SPONTANEOUS INTERSTITIAL MYOCARDITIS IN RABBITS.兔自发性间质性心肌炎。
J Exp Med. 1924 Sep 30;40(4):543-51. doi: 10.1084/jem.40.4.543.
5
THE PATHOGENESIS OF RHEUMATIC FEVER.风湿热的发病机制。
J Exp Med. 1924 Mar 31;39(4):497-508. doi: 10.1084/jem.39.4.497.
6
Induction of cardiac lesions, closely resembling those of rheumatic fever, in rabbits following repeated skin infections with group A streptococci.在兔子身上，经A组链球菌反复皮肤感染后诱发的心脏病变，与风湿热的病变极为相似。
J Exp Med. 1949 Jun 1;89(6):687-98. doi: 10.1084/jem.89.6.687.
7
Lesions of hypersensitivity induced in rabbits by massive injections of horse serum.通过大量注射马血清在兔子身上诱发的超敏反应病变。
Am J Pathol. 1949 May;25(3):413-45.
8
Cardiac lesions produced in rabbits by massive injections of bovine serum gamma globulin.通过大量注射牛血清γ球蛋白在兔子身上产生的心脏病变。
J Exp Med. 1949 May;89(5):555-60. doi: 10.1084/jem.89.5.555.
9
Experimental serum disease; a pathogenetic study.实验性血清病；一项发病机制研究。
J Exp Med. 1949 Jan;89(1):23-36. doi: 10.1084/jem.89.1.23.
10
The effects of various horse serum fractions in producing cardiovascular and renal lesions in rabbits.各种马血清组分对家兔心血管和肾脏病变的影响。
J Exp Med. 1949 Dec;90(6):577-94, 2 pl. doi: 10.1084/jem.90.6.577.
Zotero 插件