de Montalembert M, Lenoir G, Saint-Raymond A, Rey J, Lefrère J J
Département de Pédiatrie, Hôpital des Enfants-Malades, Paris.
J Clin Pathol. 1992 Feb;45(2):180-1. doi: 10.1136/jcp.45.2.180.
Serum vitamin K concentrations and prothrombin induced by absence of vitamin K (PIVK-II) concentrations were assayed in 43 patients with cystic fibrosis. Twenty nine showed a normal PIVKA-II and vitamin K concentrations; 14 showed an increased PIVKA-II concentration, in one of whom serum vitamin K was decreased. Although their vitamin K concentrations were normal, some patients with cystic fibrosis still had an increased PIVKA-II. There was a significant correlation between PIVKA-II concentrations and the administration of antibiotics, a factor which has not previously been considered responsible for an increase in PIVKA-II.
对43例囊性纤维化患者测定了血清维生素K浓度及因维生素K缺乏诱导的凝血酶原（PIVK-II）浓度。29例患者的PIVKA-II和维生素K浓度正常；14例患者的PIVKA-II浓度升高，其中1例患者血清维生素K降低。尽管一些囊性纤维化患者的维生素K浓度正常，但他们的PIVKA-II仍升高。PIVKA-II浓度与抗生素的使用之间存在显著相关性，而抗生素此前未被认为是导致PIVKA-II升高的原因。
