Miyazawa M, Nishio J, Wehrly K, David C S, Chesebro B
Laboratory of Persistent Viral Diseases, National Institutes of Health, National Institute of Allergy and Infections Diseases, Hamilton, MT 59840.
J Immunol. 1992 Mar 15;148(6):1964-7.
The Rfv-2 gene that influences the rate of spontaneous recovery from erythroleukemia induced by a low dose of Friend retrovirus complex was mapped to the Q/TL region of mouse MHC. Rfv-2 was physically and functionally distinct from the I-A-linked Ir gene that has been shown to control the responsiveness of Th cells to the envelope glycoprotein of Friend murine leukemia helper virus. The negative effect of the Rfv-2s allele was overcome by the B10.D2-H-2dm1 mutation of the D-L genes of H-2, suggesting functional similarities between the D-L and Q/TL genes in influencing resistance against Friend murine leukemia retrovirus complex infection or possible modification of Q/TL expression by genes in the D-L region.
影响低剂量Friend逆转录病毒复合物诱导的红白血病自发恢复率的Rfv-2基因被定位到小鼠MHC的Q/TL区域。Rfv-2在物理和功能上与I-A连锁的Ir基因不同，后者已被证明可控制Th细胞对Friend鼠白血病辅助病毒包膜糖蛋白的反应性。H-2的D-L基因的B10.D2-H-2dm1突变克服了Rfv-2s等位基因的负面影响，这表明D-L和Q/TL基因在影响对Friend鼠白血病逆转录病毒复合物感染的抗性方面具有功能相似性，或者D-L区域的基因可能对Q/TL表达进行修饰。
