Chesebro B, Wehrly K
J Immunol. 1978 Apr;120(4):1081-5.
Two genes, Rfv-1 and Rfv-2, that influence recovery from Friend virus leukemia have been identified within or adjacent to the mouse major histocompatibility gene complex (H-2). Rfv-1 was determined to be in the H-2G or H-2D regions by testing of mice with recombinations both to the left and right of these regions. Rfv-2 was located either in the H-2K or H-2I regions or in the Tla region. The Rfv-2 effect was not seen in the high recovery H-2D(Rfv-1)b/b mice. This could be an indication that this gene is weaker than Rfv-1 in its influence on leukemia. The influence of H-2 on recovery from leukemia appeared to operate in a gene-dose fashion (H-2b/b greater than H-2a/b greater than H-2a/a).
已在小鼠主要组织相容性基因复合体（H-2）内部或其附近鉴定出两个影响从弗瑞德病毒白血病中恢复的基因，即Rfv-1和Rfv-2。通过对这些区域左右两侧发生重组的小鼠进行测试，确定Rfv-1位于H-2G或H-2D区域。Rfv-2位于H-2K或H-2I区域或Tla区域。在高恢复率的H-2D（Rfv-1）b/b小鼠中未观察到Rfv-2效应。这可能表明该基因在对白血病的影响方面比Rfv-1弱。H-2对白血病恢复的影响似乎以基因剂量方式起作用（H-2b/b＞H-2a/b＞H-2a/a）。
