鉴定一种影响从弗氏病毒复合物诱导的病毒血症和白血病中恢复的非H-2基因（Rfv-3）。
Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.
作者信息
Chesebro B, Wehrly K
出版信息
Proc Natl Acad Sci U S A. 1979 Jan;76(1):425-9. doi: 10.1073/pnas.76.1.425.
Abstract
The dominant C57BL/10 allele of a single autosomal, non-H-2 gene (Rfv-3) was found to be required for recovery from viremia and leukemia induced by Friend virus complex in H-2b/b mice. In H-2a/a mice, the Rfv-3 gene apparently influenced recovery from viremia in the presence of persistent leukemia because these mice lacked the appropriate H-2 genotype for recovery from leukemia. The Rfv-3 gene was distinct from the Fv-2 gene because recovery from viremia was seen in recombinant-inbred mice with the Fv-2s/s genotype. Furthermore, backcross studies indicated that Rfv-3 and Fv-2 were not linked. The Rfv-3 gene may act by influencing the specific anti-FV humoral antibody response.
摘要
发现单个常染色体非H - 2基因（Rfv - 3）的显性C57BL / 10等位基因是H - 2b/b小鼠从弗瑞德病毒复合物诱导的病毒血症和白血病中恢复所必需的。在H - 2a/a小鼠中，Rfv - 3基因显然在存在持续性白血病的情况下影响从病毒血症中的恢复，因为这些小鼠缺乏从白血病中恢复所需的合适H - 2基因型。Rfv - 3基因与Fv - 2基因不同，因为在具有Fv - 2s/s基因型的重组近交小鼠中观察到了从病毒血症中的恢复。此外，回交研究表明Rfv - 3和Fv - 2不连锁。Rfv - 3基因可能通过影响特异性抗FV体液抗体反应而起作用。
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Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.鉴定一种影响从弗氏病毒复合物诱导的病毒血症和白血病中恢复的非H-2基因（Rfv-3）。
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B-tropic Friend virus: a host-range pseudotype of spleen focus-forming virus (SFFV).B嗜异性Friend病毒：脾脏灶形成病毒（SFFV）的宿主范围假型。
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Host genetic control of recovery from Friend leukemia virus-induced splenomegaly: mapping of a gene within the major histocompatability complex.宿主对弗氏白血病病毒诱导的脾肿大恢复的遗传控制：主要组织相容性复合体内一个基因的定位
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