Morizaki J
Department of Obstetrics and Gynecology, Yamagata University School of Medicine.
Nihon Sanka Fujinka Gakkai Zasshi. 1992 Jan;44(1):41-8.
I performed the following studies to confirm the recent recognition of chorioamnionitis as a cause of preterm labor and to evaluate the effect of antibiotics in the treatment of this disease. 1. Models of chorioamnionitis were prepared using prepartal rabbits by directly inoculating bacteria at various concentrations into the amniotic cavity. Preterm deliveries occurred 2-3 days after inoculation in most of the animals when given no antibiotic, but not when treated with antibiotic after inoculation at 10(3) cells/ml or less. 2. These results were confirmed pathologically and bacteriologically in animals sacrificed 3 days after inoculation. 3. When morphologies of the placenta and umbilical cord obtained at various gestational weeks were examined, it was revealed that patients developing preterm labor or PROM before 33 gestational weeks had significantly severer inflammation than did others. 4. While I have undertaken antibiotic therapy in PROM patients since April, 1985, it has been noted that the length of time between its diagnosis and delivery can be prolonged by antibiotic therapy and that such treatment can also prevent neonatal infection. Thus it is concluded that infection is a cause of preterm labor and should therefore be treated with antibiotics to prevent preterm labor without hesitation.
我进行了以下研究，以证实近期关于绒毛膜羊膜炎是早产原因的认识，并评估抗生素对该病的治疗效果。1. 使用产前家兔制备绒毛膜羊膜炎模型，通过将不同浓度的细菌直接接种到羊膜腔中。在大多数未给予抗生素的动物中，接种后2 - 3天发生早产，但在接种10(3) 个细胞/毫升或更低浓度后给予抗生素治疗的动物中未发生早产。2. 在接种后3天处死的动物中，通过病理和细菌学方法证实了这些结果。3. 检查不同孕周获得的胎盘和脐带的形态时发现，孕33周前发生早产或胎膜早破的患者的炎症明显比其他人严重。4. 自1985年4月以来，我对胎膜早破患者进行了抗生素治疗，已注意到抗生素治疗可延长从诊断到分娩的时间，并且这种治疗还可预防新生儿感染。因此得出结论，感染是早产的一个原因，因此应毫不犹豫地用抗生素治疗以预防早产。
