Patel S R, Buckner J C, Smithson W A, Scheithauer B W, Groover R V
Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905.
J Neurooncol. 1992 Jan;12(1):47-52. doi: 10.1007/BF00172456.
We report a retrospective review of our experience with cisplatin-based chemotherapy in eight patients (ages 9-44 years) with histologically confirmed primary central nervous system germ cell tumors. Five patients received chemotherapy as the primary treatment, radiation therapy being administered either at completion of chemotherapy or between chemotherapy courses. Three patients received cisplatin-based chemotherapy for recurrent disease after prior radiation therapy and/or surgery. Four of five patients treated with chemotherapy at diagnosis are in complete remission at 11-14 months from diagnosis. The remaining patient twice achieved complete remission prior to dying of progressive disease 16 months after diagnosis. Two of three patients treated with chemotherapy for recurrent disease are in complete remission at 20 and 26 months; the remaining patient deteriorated after the first cycle of chemotherapy and expired six months thereafter. Overall, of seven patients evaluable for response, five achieved complete remission with chemotherapy alone, and two with chemotherapy and radiation therapy. Our results confirm previous reports of high complete remission rates utilizing cisplatin-based chemotherapy in conjunction with radiation therapy. Prospective evaluation of cisplatin-based chemotherapy followed by radiation therapy is warranted.
我们报告了对8例（年龄9 - 44岁）经组织学确诊的原发性中枢神经系统生殖细胞肿瘤患者采用顺铂化疗的经验回顾。5例患者接受化疗作为主要治疗，放疗在化疗结束时或化疗疗程之间进行。3例患者在先前放疗和/或手术后因疾病复发接受基于顺铂的化疗。5例诊断时接受化疗的患者中有4例在诊断后11 - 14个月完全缓解。其余1例患者在诊断后16个月死于疾病进展前两次达到完全缓解。3例因疾病复发接受化疗的患者中有2例在20个月和26个月时完全缓解；其余1例患者在化疗第一周期后病情恶化，6个月后死亡。总体而言，在7例可评估反应的患者中，5例仅通过化疗达到完全缓解，2例通过化疗和放疗达到完全缓解。我们的结果证实了先前关于使用基于顺铂的化疗联合放疗具有高完全缓解率的报道。有必要对基于顺铂的化疗后再进行放疗进行前瞻性评估。
