Rainov N G, Holzhausen H J, Burkert W
Department of Neurosurgery, Faculty of Medicine, Martin-Luther-University Halle, Fed. Rep. of Germany.
Neurosurg Rev. 1995;18(4):285-92. doi: 10.1007/BF00383883.
Intracranial germinomas are lesions with a varying, rather benign growth potential, and account for only 0.3 to 1.5% of all brain tumors. About 70% of the patients with these tumors are between 10 and 21 years of age at diagnosis. Germinomas are radiosensitive and respond well also to chemotherapy. The case of a 22-year-old male patient with a giant primary intracranial germinoma originating in the pineal region is presented. Clinical signs and symptoms are described together with neuroradiological, light-microscopic, and immunohistochemical findings. The tumor was irradiated with a total dose of 46 Gy and disappeared completely already after an effective tumor dose of 30 Gy. No recurrence was seen during a follow-up of three years. The patient's quality of life could be preserved and a complete cure was achieved.
颅内生殖细胞瘤是一种生长潜力各异、相对良性的病变，仅占所有脑肿瘤的0.3%至1.5%。这些肿瘤患者中约70%在诊断时年龄介于10至21岁之间。生殖细胞瘤对放疗敏感，对化疗反应也良好。本文介绍了一名22岁男性患者，其患有起源于松果体区的巨大原发性颅内生殖细胞瘤。文中描述了临床体征和症状以及神经放射学、光学显微镜和免疫组化检查结果。该肿瘤接受了46 Gy的总剂量照射，在有效肿瘤剂量达到30 Gy后就已完全消失。在三年的随访期间未见复发。患者的生活质量得以保留，实现了完全治愈。
