Bons N, Mestre N, Petter A
Laboratorie de Neuromorphologie Fonctionnelle, Ecole Pratique des Hautes Etudes Université de Montpellier II, France.
Neurobiol Aging. 1992 Jan-Feb;13(1):99-105. doi: 10.1016/0197-4580(92)90016-q.
In some aged Microcebus brains (8- to 11-year-old animals) dramatic atrophy is found, particularly of the cortex, the hippocampus, the basal ganglia, the brainstem and the cerebellum, associated with a conspicuous increase in the size of the cerebral ventricles. These morphological changes are accompanied by certain histological profiles indicative of pathology. In the cortex, these histological changes consist of 1) a large number of senile plaques composed of degenerated neurites sometimes surrounding an amyloid plaque, 2) amyloid deposits in the vascular walls and 3) dense bundles of argyrophilic filaments in numerous pyramidal neurons. All these lesions resemble changes associated with Alzheimer's disease in man. The degenerative changes observed in the Microcebus brain are accompanied by behavioral changes. At the moment these preliminary studies, carried out on the smallest of all primates, do not prove that the degeneration is of the Alzheimer type, but do indicate that Microcebus murinus may well be a good model for the study of cerebral aging, providing a comparison with cerebral ageing in humans. The size, life span and cost of the animal provide further advantages when compared with other nonhuman primates.
在一些老年小鼠狐猴的大脑中（8至11岁的动物），发现了明显的萎缩，特别是皮质、海马体、基底神经节、脑干和小脑，同时脑室大小显著增加。这些形态学变化伴随着某些指示病理学的组织学特征。在皮质中，这些组织学变化包括：1）大量由退化神经突组成的老年斑，有时围绕着淀粉样斑块；2）血管壁中的淀粉样沉积物；3）众多锥体神经元中有嗜银细丝密集束。所有这些病变都类似于人类阿尔茨海默病相关的变化。在小鼠狐猴大脑中观察到的退行性变化伴随着行为变化。目前，这些对所有灵长类中最小的动物进行的初步研究并未证明这种退化是阿尔茨海默型的，但确实表明小鼠狐猴很可能是研究大脑衰老的良好模型，可与人类大脑衰老进行比较。与其他非人类灵长类动物相比，该动物的体型、寿命和成本具有进一步的优势。
