Bons N, Mestre N, Ritchie K, Petter A, Podlisny M, Selkoe D
Ecole Pratique des Hautes Etudes, Université de Montpellier II.
Neurobiol Aging. 1994 Mar-Apr;15(2):215-20. doi: 10.1016/0197-4580(94)90115-5.
The deposition of amyloid beta (A beta) protein in the brain has been demonstrated immunocytochemically in the small Lemurian primate Microcebus murinus. Both meningocerebral vascular deposits and cortical parenchymal deposits occur. All eight aged (> 8 years old) Microcebus examined showed vascular amyloid deposits, whereas only four exhibited parenchymal plaques. The vascular amyloid infiltrated the tunica media of the leptomeningeal and cortical arteries and arterioles and was also found in capillaries. A beta was observed to be deposited in three general forms in the cortical neuropil: round or elliptical plaques that were thioflavin-negative but sometimes showed a central concentration of A beta immunoreactivity; round plaques with a densely immunoreactive core that was thioflavin-positive; extensive ribbon-like infiltrations enclosing multiple cortical blood vessels. These observations, taken together with previous descriptions of age-related neurodegenerative changes in Microcebus, indicate that this species undergoes a beta-amyloid-associated neuropathology highly similar to that seen in Alzheimer's disease. We conclude that this lemurian primate of small size and relatively short life expectancy, provides a compelling animal model of some principal features of Alzheimer's disease.
在小型狐猴科灵长类动物小鼠狐猴的大脑中，已通过免疫细胞化学方法证实了β淀粉样蛋白（Aβ）的沉积。脑膜脑血管沉积物和皮质实质沉积物均有出现。所检查的8只老年（> 8岁）小鼠狐猴均显示有血管淀粉样沉积物，而只有4只出现实质斑块。血管淀粉样蛋白浸润软脑膜和皮质动脉及小动脉的中膜，也见于毛细血管。在皮质神经毡中观察到Aβ以三种一般形式沉积：圆形或椭圆形斑块，硫黄素染色阴性，但有时显示Aβ免疫反应性的中央聚集；具有硫黄素染色阳性的密集免疫反应性核心的圆形斑块；围绕多个皮质血管的广泛带状浸润。这些观察结果，连同先前对小鼠狐猴与年龄相关的神经退行性变化的描述，表明该物种经历了与β淀粉样蛋白相关的神经病理学，与阿尔茨海默病中所见的高度相似。我们得出结论，这种体型小且预期寿命相对较短的狐猴科灵长类动物，为阿尔茨海默病的一些主要特征提供了一个有说服力的动物模型。
