Gasser P
Medizinische Abteilung St.-Clara-Spital, Basel.
Schweiz Rundsch Med Prax. 1992 Feb 25;81(9):243-5.
Idiopathic Raynaud's disease is characterized by abnormally prolonged episodic peripheral vasospasm in response to cold or emotional stimuli. Its pathogenetic mechanism remains still unknown, although two theories attempt to explain it. Raynaud hypothesized an overactivity of the sympathetic nervous system, whereas Lewis postulated a 'local defect' at the level of precapillary resistance vessels. The controversy in both theories is discussed with respect to our knowledge of general and local control mechanisms in the peripheral vasculature.
特发性雷诺氏病的特征是在受到寒冷或情绪刺激时，外周血管痉挛发作异常延长。尽管有两种理论试图对此进行解释，但其发病机制仍然不明。雷诺假设交感神经系统活动过度，而刘易斯则推测在毛细血管前阻力血管水平存在“局部缺陷”。结合我们对外周血管系统中一般和局部控制机制的了解，对这两种理论中的争议进行了讨论。
