Parke A L
University of Connecticut Health Center, Farmington.
Curr Opin Rheumatol. 1992 Feb;4(1):68-75.
Abnormal exposure to bacterial or dietary antigen across a diseased bowel wall may result in extraintestinal clinical complaints. Persistence of this antigen for years at these extraintestinal sites does occur, resulting in chronic and sometimes autoreactive disease. Treating the bowel disease can "cure" the extraintestinal complaints, but identifying the etiology of the original bowel disorder remains a problem, especially with the inflammatory bowel diseases. In 1992, nonsteroidal anti-inflammatory drugs remain essential in the treatment of various rheumatologic complaints. Although these drugs do work, they also produce gastrointestinal disease that may be far more extensive than was formerly appreciated. This risk is obviously a problem, and those who demand a change in our therapeutic approach to arthritis probably have the right idea.
细菌或饮食抗原异常透过病变的肠壁可能导致肠外临床症状。这些抗原确实会在这些肠外部位持续存在数年，从而引发慢性疾病，有时甚至是自身反应性疾病。治疗肠道疾病可以“治愈”肠外症状，但确定原发性肠道疾病的病因仍然是个问题，尤其是对于炎症性肠病。1992年，非甾体抗炎药在治疗各种风湿性疾病方面仍然至关重要。虽然这些药物确实有效，但它们也会引发胃肠道疾病，其范围可能比以前认为的要广泛得多。这种风险显然是个问题，那些要求改变我们治疗关节炎方法的人可能是正确的。
