小鼠主要组织相容性复合体编码一种细菌核糖体蛋白S13的哺乳动物同源物。
The murine MHC encodes a mammalian homolog of bacterial ribosomal protein S13.
作者信息
MacMurray A J, Shin H S
机构信息
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
出版信息
Mamm Genome. 1992;2(2):87-95. doi: 10.1007/BF00353855.
The mouse major histocompatibility complex (MHC) contains many genes in addition to the classical immune response genes. We have screened overlapping cosmid clones covering 170 kb of the H-2K region for genes expressed in embryonal carcinoma (EC) cells. The Ke-3 gene (Abe et al. 1988) found in this region was further studied by Southern, Northern, and sequence analysis. It is an expressed, intron-containing locus encoding a mouse homolog of the bacterial ribosomal protein S13. This is the first non-organelle S13 homolog identified in metazoans, and its genomic location has been determined precisely.
小鼠主要组织相容性复合体（MHC）除了经典的免疫反应基因外还包含许多基因。我们筛选了覆盖H-2K区域170 kb的重叠黏粒克隆，以寻找在胚胎癌细胞（EC）中表达的基因。对该区域发现的Ke-3基因（Abe等人，1988年）进行了Southern、Northern和序列分析。它是一个表达的、含内含子的基因座，编码细菌核糖体蛋白S13的小鼠同源物。这是后生动物中鉴定出的第一个非细胞器S13同源物，并且其基因组位置已被精确确定。
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