Annis H M, Peachey J E
Addiction Research Foundation, Toronto, Ontario, Canada.
Br J Addict. 1992 Jan;87(1):63-72. doi: 10.1111/j.1360-0443.1992.tb01901.x.
The effect of combining relapse prevention counselling with use of an alcohol-sensitizing drug was examined. Fifty-six alcoholic subjects who participated in a clinical trial of the short-acting alcohol sensitizing drug, citrated calcium carbimide, were randomly assigned to: (i) a Physician Advice condition in which subjects took the drug within a context designed to reinforce the medical management of their drinking problem; and (ii) a Relapse Prevention condition in which subjects were instructed to pair use of the drug with planned entry into high risk drinking situations and to gradually reduce reliance on the drug by developing alternative coping behaviour patterns. As predicted, subjects receiving carbimide in conjunction with relapse prevention counselling showed significant growth in internal attribution for change; whereas those receiving carbimide under more traditional medical management showed no movement toward internality. On measurement of alcohol consumption at 6, 12 and 18 months follow-up, there was some indication of superior maintenance of treatment gains at 18 months post-treatment for subjects who had received relapse prevention counselling, although the effect did not reach a conventional level of significance (F = 2.82; P less than 0.06). The findings are interpreted as consistent with a cognitive social-learning analysis of the maintenance of behaviour change.
研究了将预防复发咨询与使用酒精增敏药物相结合的效果。56名参与短效酒精增敏药物枸橼酸钙双脒临床研究的酗酒受试者被随机分为：（i）医生建议组，受试者在旨在强化对其饮酒问题进行医疗管理的背景下服用药物；（ii）预防复发组，受试者被指导在计划进入高风险饮酒情境时服用药物，并通过发展替代应对行为模式逐渐减少对药物的依赖。正如所预测的，接受双脒并结合预防复发咨询的受试者在改变的内部归因方面有显著增长；而那些在更传统医疗管理下接受双脒的受试者在向内在性方面没有进展。在6个月、12个月和18个月随访时测量酒精摄入量，有迹象表明，接受预防复发咨询的受试者在治疗后18个月时，治疗效果的维持情况较好，尽管该效果未达到传统的显著水平（F = 2.82；P < 0.06）。研究结果被解释为与行为改变维持的认知社会学习分析一致。
