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来自一名华氏巨球蛋白血症患者的两种活性不同的IgM的结构。

The structure of two IgMs showing different activity from a patient with Waldenstrom's macroglobulinaemia.

作者信息

Méndez E, Osuna C, Sánchez A, Revilla Y, Soriano F, Montalbán C, Seguí J, Avila J

机构信息

Centro de Biología Molecular (CSIC-UAM), Universidad Autónoma de Madrid, Cantoblanco, Spain.

出版信息

Clin Exp Immunol. 1992 Mar;87(3):472-7. doi: 10.1111/j.1365-2249.1992.tb03022.x.

DOI:10.1111/j.1365-2249.1992.tb03022.x
PMID:1544232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1554315/
Abstract

The two monoclonal IgMs (IgM1 and IgM2) were characterized from a patient Waldenström's macroglobulinaemia that resulted in a gammapathy. Heavy and light chains were isolated from the IgM. The complete primary structure of the two light chains and the NH2-terminal region of the two heavy chain molecules were determined. The sequence data indicated that the heavy and light chains from both IgMs belong to the same (III and II) lambda subgroups. By testing their antibody activity it was found by immunofluorescence and immunoblotting that only IgM2 reacts with an intermediate filament protein.

摘要

从一名导致丙种球蛋白病的华氏巨球蛋白血症患者中鉴定出两种单克隆IgM（IgM1和IgM2）。从IgM中分离出重链和轻链。确定了两条轻链的完整一级结构以及两条重链分子的NH2末端区域。序列数据表明，两种IgM的重链和轻链均属于同一（III和II）λ亚组。通过检测它们的抗体活性，通过免疫荧光和免疫印迹发现只有IgM2与一种中间丝蛋白发生反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae30/1554315/72f2e3ae4e52/clinexpimmunol00053-0142-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae30/1554315/26ed89970d5c/clinexpimmunol00053-0139-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae30/1554315/d14217b6c651/clinexpimmunol00053-0140-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae30/1554315/7e852643fef4/clinexpimmunol00053-0141-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae30/1554315/e5e49455cd98/clinexpimmunol00053-0141-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae30/1554315/72f2e3ae4e52/clinexpimmunol00053-0142-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae30/1554315/26ed89970d5c/clinexpimmunol00053-0139-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae30/1554315/d14217b6c651/clinexpimmunol00053-0140-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae30/1554315/7e852643fef4/clinexpimmunol00053-0141-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae30/1554315/e5e49455cd98/clinexpimmunol00053-0141-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae30/1554315/72f2e3ae4e52/clinexpimmunol00053-0142-a.jpg

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