Tonegawa S
Nature. 1983 Apr 14;302(5909):575-81. doi: 10.1038/302575a0.
In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the formation of a complete gene. In addition, mutations are somatically introduced at a high rate into the amino-terminal region. Both somatic recombination and mutation contribute greatly to an increase in the diversity of antibody synthesized by a single organism.
在生殖系细胞的基因组中，免疫球蛋白多肽链的遗传信息包含在沿染色体分散的多个基因片段中。在骨髓来源的淋巴细胞发育过程中，这些基因片段通过重组进行组装，从而形成一个完整的基因。此外，体细胞会以较高的频率在氨基末端区域引入突变。体细胞重组和突变都极大地促进了单个生物体合成的抗体多样性的增加。
