Ferral H, Male R, Cardiel M, Munoz L, Quiroz y Ferrari F
Department of Radiology, Instituto Nacional de la Nutricion, Mexico D.F., Mexico.
Gastrointest Radiol. 1992 Winter;17(1):74-8. doi: 10.1007/BF01888512.
To determine the sensitivity, specificity, and predictive values of the sonographic analysis of liver surface irregularities for the diagnosis of cirrhosis, the authors conducted a prospective and blinded study in 70 subjects with abnormal liver function tests. All patients included underwent liver biopsy within 15 days of the sonographic study. Twenty-three subjects with no signs or symptoms of liver disease were examined to assess the sonographic appearance of normal liver surface. Studies were performed with a small-parts probe, high-frequency transducer (7.5 MHz). Three basic patterns of liver surface were found: type I, normal; type II, focal abnormality; and type III, diffuse irregularity. Considering diffuse surface irregularity as an objective sonographic sign of cirrhosis, the study's sensitivity was 87.5%, specificity 81.5%, and positive and negative predictive values were 80% and 88.5%, respectively. Disease prevalence for cirrhosis was 45%. We conclude that sonographic analysis of the liver surface is a useful noninvasive test for the diagnosis of cirrhosis in the appropriate clinical setting.
为了确定肝脏表面不规则超声分析对肝硬化诊断的敏感性、特异性和预测值，作者对70例肝功能检查异常的受试者进行了一项前瞻性双盲研究。所有纳入的患者在超声检查后的15天内均接受了肝活检。对23例无肝脏疾病体征或症状的受试者进行检查，以评估正常肝脏表面的超声表现。研究使用小型探头高频换能器（7.5MHz）进行。发现肝脏表面有三种基本模式：I型，正常；II型，局灶性异常；III型，弥漫性不规则。将弥漫性表面不规则视为肝硬化的客观超声征象，该研究的敏感性为87.5%，特异性为81.5%，阳性预测值和阴性预测值分别为80%和88.5%。肝硬化的疾病患病率为
