Ashwell M, Durrant M, Garrow J S
Int J Obes. 1978;2(4):449-56.
Thirty-three obese women were admitted as inpatients to a metabolic ward and had an average intake of 3.35 MJ (800 kcal) daily for three weeks. Fat biopsies were taken at three subcutaneous sites and average fat cell mass (CM) and apparent fat cell number (FCN) were calculated. There was no significant correlation between adipose tissue cellularity (CM or FCN) and total weight loss or resting metabolic rate, provided due allowances were made for the severity of obesity in each case. Neither was there any significant correlation between short-term weight loss and the age of onset of obesity. Resting metabolic rate, and not adipose tissue cellularity or age of onset of obesity, is a better indicator of short-term weight loss under controlled inpatient conditions.
33名肥胖女性作为住院患者被收治到代谢病房，连续三周每天平均摄入3.35兆焦耳（800千卡）热量。在三个皮下部位进行脂肪活检，并计算平均脂肪细胞质量（CM）和表观脂肪细胞数量（FCN）。如果对每例肥胖的严重程度进行适当校正，脂肪组织细胞构成（CM或FCN）与总体重减轻或静息代谢率之间无显著相关性。短期体重减轻与肥胖发病年龄之间也无显著相关性。在住院患者受控条件下，静息代谢率而非脂肪组织细胞构成或肥胖发病年龄，是短期体重减轻的更好指标。
