Noppa H, Bengtsson C, Isaksson B, Smith U
Int J Obes. 1980;4(3):253-63.
A population sample totalling 1462 middle-aged women was studied in 1968-69. A re-study of the same women in 1974-75 comprised 1302 women. Body composition and adipose tissue cellularity were determined in a systematic subsample of 227 women and in a subsample of 76 obese women. There was a significant relation between body build in childhood (evaluated retrospectively as lean, normal or obese) and prevalence and degree of obesity in adulthood. There was a highly significant relation between the body weights in 1968-69 and 1974-75, while a low order negative correlation was found between body weight in 1968-69 and change in weight between 1968-69 and 1974-75. There was a significant relation between fat cell weight and weight index in the lower range and between fat cell number and weight index throughout the whole range studied. Body cell mass correlated with weight index and total fat cell number but not with fat cell weight. There was no significant correlation between body cell mass and obesity in childhood. There was a significant relation between degree of obesity and total fat cell number when age of onset was kept constant, but not between age of onset and total fat cell number when degree of obesity was kept constant. An association between childhood obesity and obesity in adulthood was shown. However, the concept of a critical period in childhood for changes in total fat cell number was not supported.
1968年至1969年对总计1462名中年女性的人群样本进行了研究。1974年至1975年对同一批女性进行的重新研究中有1302名女性参与。在227名女性的系统子样本和76名肥胖女性的子样本中测定了身体成分和脂肪组织细胞构成。童年时期的体型（回顾性评估为瘦、正常或肥胖）与成年期肥胖的患病率和程度之间存在显著关系。1968年至1969年与1974年至1975年的体重之间存在高度显著的关系，而1968年至1969年的体重与1968年至1969年和1974年至1975年之间的体重变化呈低阶负相关。在所研究的整个范围内，脂肪细胞重量与较低范围内的体重指数之间以及脂肪细胞数量与体重指数之间存在显著关系。身体细胞量与体重指数和总脂肪细胞数量相关，但与脂肪细胞重量无关。身体细胞量与童年肥胖之间没有显著相关性。当发病年龄保持恒定时，肥胖程度与总脂肪细胞数量之间存在显著关系，但当肥胖程度保持恒定时，发病年龄与总脂肪细胞数量之间不存在显著关系。童年肥胖与成年肥胖之间存在关联。然而，童年时期总脂肪细胞数量变化的关键期概念未得到支持。
