Heimann R B, Schürmann N, Müller R T
Department of Mineralogy, Technische Universität Bergakademie Freiberg, D-09596 Freiberg, Germany.
J Mater Sci Mater Med. 2004 Sep;15(9):1045-52. doi: 10.1023/B:JMSM.0000042691.74922.1b.
To evaluate the in vivo performance of "duplex" hydroxylapatite top coat/TiO(2) bond coat systems, cylindrical Ti6Al4V rods of 130 mm in length and 11-13 mm in diameter were coated by atmospheric plasma spray (APS) technique with both a standard hydroxylapatite (HAp) layer and a HAp+TiO(2) bond coat "duplex" layer. In this pilot study coated and uncoated rods serving as controls were implanted into the femur of sheep so that their distal ends were freely suspended in the medulla of the femur. After an observation time of six months it was found that bone apposition and bone ingrowth were considerably increased in the presence of a osteoconductive coating. In particular, in vivo spalling and delamination frequently observed with HAp coatings was virtually absent in duplex coatings owing to the strong adhesion of the bond coat to the HAp top coat that anchored the latter solidly to the metallic surface of the implant. Some tentative mechanisms leading to this improved coating adhesion will be discussed.
为评估“双相”羟基磷灰石顶层涂层/TiO₂ 粘结涂层系统的体内性能，采用大气等离子喷涂（APS）技术，在长度为130 mm、直径为11 - 13 mm的圆柱形Ti6Al4V棒材上分别涂覆标准羟基磷灰石（HAp）层和HAp + TiO₂ 粘结涂层“双相”层。在这项初步研究中，将涂覆和未涂覆的棒材作为对照植入绵羊股骨，使其远端自由悬浮在股骨骨髓中。经过六个月的观察期后发现，在存在骨传导涂层的情况下，骨附着和骨长入显著增加。特别是，由于粘结涂层与HAp顶层涂层之间的强附着力将后者牢固地锚固在植入物的金属表面，在双相涂层中几乎不存在HAp涂层中经常观察到的体内剥落和分层现象。将讨论导致这种涂层附着力改善的一些初步机制。
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