Plasma Forming Lab and Nanomechanics and Nanotribology Lab, Department of Mechanical and Materials Engineering, Florida International University, Miami, Florida 33174, United States.
ACS Nano. 2011 Jun 28;5(6):4790-9. doi: 10.1021/nn200768c. Epub 2011 May 26.
This is the first in vivo study of plasma-sprayed carbon nanotube (CNT)-reinforced hydroxyapatite (HA) coating on titanium implants embedded in rodents' bone. No adverse effect or cytotoxicity of CNT addition on bone tissues and cells was observed. Normal bone growth was observed around HA-CNT-coated implants. CNT addition induces higher osseointegration as compared to HA. Elastic modulus of new bone was compared with the modulus of HA-CNT/bone interface to understand the mechanical integrity of the implant.
这是首例将等离子喷涂碳纳米管（CNT）增强羟基磷灰石（HA）涂层应用于植入啮齿动物骨内的钛植入物的体内研究。未观察到 CNT 加入对骨组织和细胞的不良影响或细胞毒性。在 HA-CNT 涂层植入物周围观察到正常的骨生长。与 HA 相比，CNT 的加入诱导更高的骨整合。通过比较新骨的弹性模量与 HA-CNT/骨界面的模量，了解植入物的机械完整性。
