Forsmo Siri, Langhammer Arnulf, Forsen Lisa, Schei Berit
Department of Public Health and General Practice, Norwegian University of Science and Technology, Medisinsk-teknisk senter, 7489 Trondheim, Norway.
Osteoporos Int. 2005 May;16(5):562-7. doi: 10.1007/s00198-004-1726-y. Epub 2004 Sep 22.
The fracture incidence in Norway is among the highest in Europe, presumably due to osteoporosis. As part of a multipurpose health study in the county of Nord-Trondelag, Norway (the HUNT study), a 5% randomly selected sample (n=4,646) of the population >19 years of age was invited to undergo single X-ray absorptiometry (SXA) of the forearm. A total of 1,274 men (50.5 years) and 1,505 women (49.9 years) participated (60%). The aim of the study was to describe the variation in bone mineral density (BMD) and the prevalence of forearm BMD 2.5 standard deviations (SD) below the mean value for young adults in an unselected population sample. In women the BMD remained stable until the age of 50 years, whereupon a strong decline in BMD was observed. In men, a BMD increase was observed until about the age of 40 years; the decline after the age of 65 was, however, similar to that in women. Based on age and gender-specific reference values, the age-adjusted prevalence of T-scores <-2.5 SD in women and men aged 50-69 years was 16.0% and 5.6%, respectively. In the age group of 70 years or older the prevalence was 65.8% and 30.6% for women and men, respectively. The accelerated BMD reduction in women aged 50-65 explains the higher prevalence of T-score <-2.5 SD in elderly women than in men. Further studies on bone loss and falls are required to explain the high fracture incidence in Norway.
挪威的骨折发生率在欧洲位居前列,可能是由骨质疏松症所致。作为挪威北特伦德拉格郡一项多用途健康研究(HUNT研究)的一部分,随机抽取了该郡19岁以上人口的5%(n = 4646),邀请其接受前臂单能X线吸收测定法(SXA)检查。共有1274名男性(50.5岁)和1505名女性(49.9岁)参与(参与率为60%)。该研究的目的是描述在一个未经挑选的人群样本中,骨矿物质密度(BMD)的变化情况以及前臂BMD低于年轻成年人平均值2.5个标准差(SD)的患病率。女性的BMD在50岁之前保持稳定,此后观察到BMD急剧下降。男性的BMD在40岁左右之前呈上升趋势;然而,65岁之后的下降情况与女性相似。根据年龄和性别特异性参考值,50 - 69岁女性和男性的年龄调整后T值<-2.5 SD的患病率分别为16.0%和5.6%。在70岁及以上年龄组中,女性和男性的患病率分别为65.8%和30.6%。50 - 65岁女性BMD加速下降解释了老年女性中T值<-2.5 SD的患病率高于男性的原因。需要进一步开展关于骨质流失和跌倒的研究,以解释挪威骨折发生率较高的现象。