Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Bone. 2010 May;46(5):1294-8. doi: 10.1016/j.bone.2009.11.024. Epub 2009 Nov 26.
There is a substantial variation in hip fracture incidence between populations. The Scandinavian countries have the highest incidence of hip fractures worldwide, and latitude and seasonal variation have been discussed as possible reasons for the high fracture incidences. The purpose of this study was to investigate time dependent and seasonal variation of hip fractures in a population based cohort of women aged 65+ residing in a rural county in Norway and followed for 9.3 years. Information at baseline was collected as part of The Nord-Trøndelag Health Study (HUNT) during 1995-97, and 8362 women with no previous hip fracture and with a mean age of 74.3 years were included in the study. All hip fractures occurring after inclusion in the health study were registered (mean follow-up: 9.3 years) by medical journals and x-ray reports. A total of 5661 of the women had their forearm bone mineral density (BMD) measured by single energy x-ray bone densitometers (SXA) as part of HUNT. In total, 782 women sustained a first hip fracture during follow-up, and the overall hip fracture incidence rate per 1000 person-years was 13.1 (95 % CI: 12.2-14.1). The hip fracture incidence increased exponentially by age from 2.1 (95% CI: 1.2-3.8) in the age group 65-69 years to 49.7 (95% CI: 41.2-59.8) among the women aged 90+, respectively. In age-stratified analyses no changes in the incidence of hip fractures were observed during the nine years of follow up. The occurrence of fractures varied by season of the year, characterized by higher fracture rates during the winter months. In conclusion, the hip fracture rates in this population of elderly women are highest in the winter months. There was, however, no indication of an increasing hip fracture incidence in this rural area. Compared to similar studies from more urban areas in Norway, the hip fracture rates in this population seem somewhat lower.
人群之间髋部骨折的发生率存在很大差异。斯堪的纳维亚国家的髋部骨折发生率居世界首位,纬度和季节性变化已被认为是高骨折发生率的可能原因。本研究旨在调查挪威农村县一个 65 岁以上的人群队列中髋部骨折的时间依赖性和季节性变化,并对其进行了 9.3 年的随访。基线信息是作为 1995-97 年期间的北特伦德拉格健康研究(HUNT)的一部分收集的,该研究包括 8362 名无先前髋部骨折且平均年龄为 74.3 岁的女性。所有在健康研究纳入后发生的髋部骨折均通过医学期刊和 X 射线报告进行登记(平均随访:9.3 年)。共有 5661 名女性作为 HUNT 的一部分通过单能 X 射线骨密度仪(SXA)测量了前臂骨密度(BMD)。在随访期间,共有 782 名女性发生了首次髋部骨折,每 1000 人年的总体髋部骨折发生率为 13.1(95%CI:12.2-14.1)。髋部骨折发生率随年龄呈指数增长,从 65-69 岁年龄组的 2.1(95%CI:1.2-3.8)增加到 90 岁以上女性的 49.7(95%CI:41.2-59.8)。在年龄分层分析中,在 9 年的随访期间,髋部骨折的发生率没有变化。骨折的发生与一年中的季节有关,冬季骨折发生率较高。总之,该老年女性人群的髋部骨折发生率在冬季最高。然而,在这个农村地区没有迹象表明髋部骨折的发生率在增加。与挪威更城市化地区的类似研究相比,该人群的髋部骨折发生率似乎略低。