Emaus N, Berntsen G K R, Joakimsen R, Fonnebø V
Institute of Community Medicine, Faculty of Medicine, University of Tromsø, Tromsø, Norway.
Am J Epidemiol. 2006 Mar 1;163(5):441-9. doi: 10.1093/aje/kwj055. Epub 2006 Jan 4.
The aim of this study was to describe changes in bone mineral density in Norwegian women and men aged 45-84 years in a population-based, longitudinal study. Bone mineral density (g/cm2) was measured at distal and ultradistal forearm sites with single x-ray absorptiometric devices in 3,169 women and 2,197 men at baseline in 1994-1995 and at follow-up in 2001 (standard deviation, 0.4 years). The mean annual bone loss was -0.5% and -0.4% in men and -0.9% and -0.8% in women not using hormone replacement therapy at the distal and ultradistal sites, respectively. In men, age was a negative predictor of bone mineral density change at both sites. Women not using hormone replacement therapy had the highest bone loss at the ultradistal site 1-5 years after menopause. The correlation between the two measurements was high: r = 0.93 and r = 0.90 in women and r = 0.96 and r = 0.93 in men for the distal and ultradistal sites, respectively. More than 70% kept their quartile positions, indicating a high degree of tracking of bone mineral density measurements. Although the study population live above the polar circle, the rate of bone loss was not higher at the distal and ultradistal forearm sites compared with that of other cohorts.
本研究旨在通过一项基于人群的纵向研究，描述挪威45至84岁女性和男性骨矿物质密度的变化。1994 - 1995年基线时，使用单能X线吸收测定仪在3169名女性和2197名男性的前臂远端和超远端部位测量骨矿物质密度（g/cm²），并于2001年进行随访（标准差为0.4年）。在未使用激素替代疗法的男性中，前臂远端和超远端部位的年均骨丢失率分别为-0.5%和-0.4%；在未使用激素替代疗法的女性中，相应部位的年均骨丢失率分别为-0.9%和-0.8%。在男性中，年龄是两个部位骨矿物质密度变化的负向预测因素。未使用激素替代疗法的女性在绝经后1至5年超远端部位的骨丢失最为严重。两次测量之间的相关性很高：女性前臂远端和超远端部位的r值分别为0.93和0.90，男性相应部位的r值分别为0.96和0.93。超过70%的人保持其四分位数位置，表明骨矿物质密度测量具有高度的追踪性。尽管研究人群生活在北极圈以上，但与其他队列相比，前臂远端和超远端部位的骨丢失率并不更高。
